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dc.contributor.authorHunter, Kylie E
dc.contributor.authorJohnson, Brittany J
dc.contributor.authorAskie, Lisa
dc.contributor.authorGolley, Rebecca K
dc.contributor.authorBaur, Louise A
dc.contributor.authorMarschner, Ian C
dc.contributor.authorTaylor, Rachael W
dc.contributor.authorWolfenden, Luke
dc.contributor.authorWood, Charles T
dc.contributor.authorMihrshahi, Seema
dc.contributor.authorHayes, Alison J
dc.contributor.authorRissel, Chris
dc.contributor.authorRobledo, Kristy P
dc.contributor.authorO'Connor, Denise A
dc.contributor.authorEspinoza, David
dc.contributor.authorStaub, Lukas P
dc.contributor.authorChadwick, Paul
dc.contributor.authorTaki, Sarah
dc.contributor.authorBarba, Angie
dc.contributor.authorLibesman, Sol
dc.contributor.authorAberoumand, Mason
dc.contributor.authorSmith, Wendy A
dc.contributor.authorSue-See, Michelle
dc.contributor.authorHesketh, Kylie D
dc.contributor.authorThomson, Jessica L
dc.contributor.authorBryant, Maria
dc.contributor.authorPaul, Ian M
dc.contributor.authorVerbestel, Vera
dc.contributor.authorStough, Cathleen Odar
dc.contributor.authorWen, Li Ming
dc.contributor.authorLarsen, Junilla K
dc.contributor.authorO'Reilly, Sharleen L
dc.contributor.authorWasser, Heather M
dc.contributor.authorSavage, Jennifer S
dc.contributor.authorOng, Kenneth
dc.contributor.authorSalvy, Sarah-Jeanne
dc.contributor.authorMessito, Mary Jo
dc.contributor.authorGross, Rachel S
dc.contributor.authorKarssen, Levie T
dc.contributor.authorRasmussen, Finn E
dc.contributor.authorCampbell, Karen
dc.contributor.authorLinares, Ana Maria
dc.contributor.authorØverby, Nina Cecilie
dc.contributor.authorPalacios, Cristina
dc.contributor.authorJoshipura, Kaumudi J
dc.contributor.authorGonzález Acero, Carolina
dc.contributor.authorLakshman, Rajalakshmi
dc.contributor.authorThompson, Amanda L
dc.contributor.authorMaffeis, Claudio
dc.contributor.authorOken, Emily
dc.contributor.authorGhaderi, Ata
dc.contributor.authorCampos Rivera, Maribel
dc.contributor.authorPérez-Expósito, Ana B
dc.contributor.authorBanna, Jinan C
dc.contributor.authorde la Haye, Kayla
dc.contributor.authorGoran, Michael
dc.contributor.authorRøed, Margrethe
dc.contributor.authorAnzman-Frasca, Stephanie
dc.contributor.authorTaylor, Barry J
dc.contributor.authorSeidler, Anna Lene
dc.contributor.authorTransforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
dc.description.abstractINTRODUCTION: Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. METHODS AND ANALYSIS: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. ETHICS AND DISSEMINATION: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO REGISTRATION NUMBER: CRD42020177408.
dc.rightsAttribution-NonCommercial 4.0 International
dc.subjectcommunity child health
dc.subjectpreventive medicine
dc.subjectpublic health
dc.titleTransforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.
dc.publisher.departmentDepartment of Paediatrics
prism.publicationNameBMJ Open
dc.contributor.orcidHunter, Kylie E [0000-0002-2796-9220]
dc.contributor.orcidJohnson, Brittany J [0000-0001-5492-9219]
dc.contributor.orcidO'Connor, Denise A [0000-0002-6836-122X]
dc.contributor.orcidHesketh, Kylie D [0000-0002-2702-7110]
dc.contributor.orcidOng, Kenneth [0000-0003-4689-7530]
dc.contributor.orcidØverby, Nina Cecilie [0000-0002-1871-041X]
dc.contributor.orcidSeidler, Anna Lene [0000-0002-0027-1623]
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (MC_UU_00006/2)
pubs.licence-display-nameApollo Repository Deposit Licence Agreement

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Attribution-NonCommercial 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial 4.0 International