Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.
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Authors
Askie, Lisa
Golley, Rebecca K
Baur, Louise A
Marschner, Ian C
Taylor, Rachael W
Wolfenden, Luke
Wood, Charles T
Mihrshahi, Seema
Hayes, Alison J
Rissel, Chris
Robledo, Kristy P
Espinoza, David
Staub, Lukas P
Chadwick, Paul
Taki, Sarah
Barba, Angie
Libesman, Sol
Aberoumand, Mason
Smith, Wendy A
Sue-See, Michelle
Thomson, Jessica L
Bryant, Maria
Paul, Ian M
Verbestel, Vera
Stough, Cathleen Odar
Wen, Li Ming
Larsen, Junilla K
O'Reilly, Sharleen L
Wasser, Heather M
Savage, Jennifer S
Salvy, Sarah-Jeanne
Messito, Mary Jo
Gross, Rachel S
Karssen, Levie T
Rasmussen, Finn E
Campbell, Karen
Linares, Ana Maria
Palacios, Cristina
Joshipura, Kaumudi J
González Acero, Carolina
Lakshman, Rajalakshmi
Thompson, Amanda L
Maffeis, Claudio
Oken, Emily
Ghaderi, Ata
Campos Rivera, Maribel
Pérez-Expósito, Ana B
Banna, Jinan C
de la Haye, Kayla
Goran, Michael
Røed, Margrethe
Anzman-Frasca, Stephanie
Taylor, Barry J
Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
Publication Date
2022-01-20Journal Title
BMJ Open
ISSN
2044-6055
Publisher
BMJ
Volume
12
Issue
1
Pages
e048166
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Hunter, K. E., Johnson, B. J., Askie, L., Golley, R. K., Baur, L. A., Marschner, I. C., Taylor, R. W., et al. (2022). Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.. BMJ Open, 12 (1), e048166. https://doi.org/10.1136/bmjopen-2020-048166
Abstract
INTRODUCTION: Behavioural interventions in early life appear to show some effect in reducing childhood overweight and obesity. However, uncertainty remains regarding their overall effectiveness, and whether effectiveness differs among key subgroups. These evidence gaps have prompted an increase in very early childhood obesity prevention trials worldwide. Combining the individual participant data (IPD) from these trials will enhance statistical power to determine overall effectiveness and enable examination of individual and trial-level subgroups. We present a protocol for a systematic review with IPD meta-analysis to evaluate the effectiveness of obesity prevention interventions commencing antenatally or in the first year after birth, and to explore whether there are differential effects among key subgroups. METHODS AND ANALYSIS: Systematic searches of Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), PsycInfo and trial registries for all ongoing and completed randomised controlled trials evaluating behavioural interventions for the prevention of early childhood obesity have been completed up to March 2021 and will be updated annually to include additional trials. Eligible trialists will be asked to share their IPD; if unavailable, aggregate data will be used where possible. An IPD meta-analysis and a nested prospective meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome will be body mass index z-score at age 24±6 months using WHO Growth Standards, and effect differences will be explored among prespecified individual and trial-level subgroups. Secondary outcomes include other child weight-related measures, infant feeding, dietary intake, physical activity, sedentary behaviours, sleep, parenting measures and adverse events. ETHICS AND DISSEMINATION: Approved by The University of Sydney Human Research Ethics Committee (2020/273) and Flinders University Social and Behavioural Research Ethics Committee (HREC CIA2133-1). Results will be relevant to clinicians, child health services, researchers, policy-makers and families, and will be disseminated via publications, presentations and media releases. PROSPERO REGISTRATION NUMBER: CRD42020177408.
Keywords
community child health, paediatrics, preventive medicine, public health
Sponsorship
MRC (MC_UU_00006/2)
Identifiers
External DOI: https://doi.org/10.1136/bmjopen-2020-048166
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333411
Rights
Attribution-NonCommercial 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc/4.0/
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