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dc.contributor.authorKitilya, Brenda
dc.contributor.authorPrayGod, George
dc.contributor.authorPeck, Robert
dc.contributor.authorChangalucha, John
dc.contributor.authorJeremiah, Kidola
dc.contributor.authorKavishe, Bazil Baltazar
dc.contributor.authorFriis, Henrik
dc.contributor.authorFilteau, Suzanne
dc.contributor.authorFaurholt-Jepsen, Daniel
dc.contributor.authorKrogh-Madsen, Rikke
dc.contributor.authorBrage, Soren
dc.contributor.authorOlsen, Mette F
dc.date.accessioned2022-01-29T00:30:58Z
dc.date.available2022-01-29T00:30:58Z
dc.date.issued2022-01-21
dc.identifier.issn1932-6203
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333412
dc.description.abstract<h4>Introduction</h4>In the HIV-infected individuals, physical activity improves physical strength, quality of life and reduces the risk of developing non-communicable diseases. In Sub-Saharan Africa, HIV-infected patients report being less active compared to HIV-uninfected individuals. We assessed the levels and correlates of objectively measured physical activity and capacity among HIV-infected antiretroviral therapy (ART)-naive individuals compared to HIV-uninfected individuals in Mwanza, Tanzania.<h4>Method</h4>We conducted a cross-sectional study among newly diagnosed HIV-infected ART-naive individuals and HIV-uninfected individuals frequency-matched for age and sex. Socio-demographic data, anthropometrics, CD4 counts, haemoglobin level, and C-reactive protein (CRP) were collected. Physical activity energy expenditure (PAEE) was assessed as measure of physical activity whereas sleeping heart rate (SHR) and grip strength were assessed as measures of physical capacity. Multivariable linear regression was used to assess the correlates associated with physical activity and capacity.<h4>Results</h4>A total of 272 HIV-infected and 119 HIV-uninfected individuals, mean age 39 years and 60% women participated in the study. Compared to HIV-uninfected individuals, HIV-infected had poorer physical activity and capacity: lower PAEE (-7.3 kj/kg/day, 95% CI: -11.2, -3.3), elevated SHR (7.7 beats/min, 95%CI: 10.1, 5.3) and reduced grip strength (-4.7 kg, 95%CI: -6.8, -2.8). In HIV-infected individuals, low body mass index, moderate-severe anaemia, low CD4 counts and high CRP were associated with lower physical activity and capacity. In HIV-uninfected individuals, abdominal obesity and moderate anaemia were associated with lower physical activity and capacity.<h4>Conclusion</h4>HIV-infected participants had lower levels of physical activity and capacity than HIV-uninfected participants. Correlates of physical activity and capacity differed by HIV status. Management of HIV and related conditions needs to be provided effectively in health care facilities. Interventions promoting physical activity in these populations will be of importance to improve their health and reduce the risk of non-communicable diseases.
dc.format.mediumElectronic-eCollection
dc.publisherPublic Library of Science (PLoS)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleLevels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals.
dc.typeArticle
dc.publisher.departmentMrc Epidemiology Unit
dc.date.updated2022-01-28T11:55:56Z
prism.issueIdentifier1
prism.publicationDate2022
prism.publicationNamePloS one
prism.startingPagee0262298
prism.volume17
dc.identifier.doi10.17863/CAM.80836
rioxxterms.versionofrecord10.1371/journal.pone.0262298
rioxxterms.versionVoR
dc.contributor.orcidKitilya, Brenda [0000-0003-0734-5944]
dc.contributor.orcidKavishe, Bazil Baltazar [0000-0003-4839-4590]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidOlsen, Mette F [0000-0002-5742-6403]
dc.identifier.eissn1932-6203
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMRC (MC_UU_00006/4)
cam.issuedOnline2022-01-21
cam.depositDate2022-01-28
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International