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dc.contributor.authorBettgenhaeuser, Jan
dc.contributor.authorHernández-Pinzón, Inmaculada
dc.contributor.authorDawson, Andrew M
dc.contributor.authorGardiner, Matthew
dc.contributor.authorGreen, Phon
dc.contributor.authorTaylor, Jodie
dc.contributor.authorSmoker, Matthew
dc.contributor.authorFerguson, John N
dc.contributor.authorEmmrich, Peter
dc.contributor.authorHubbard, Amelia
dc.contributor.authorBayles, Rosemary
dc.contributor.authorWaugh, Robbie
dc.contributor.authorSteffenson, Brian J
dc.contributor.authorWulff, Brande BH
dc.contributor.authorDreiseitl, Antonín
dc.contributor.authorWard, Eric R
dc.contributor.authorMoscou, Matthew J
dc.date.accessioned2022-01-31T16:21:59Z
dc.date.available2022-01-31T16:21:59Z
dc.date.issued2021-11-25
dc.date.submitted2019-05-09
dc.identifier.issn2041-1723
dc.identifier.others41467-021-27288-3
dc.identifier.other27288
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/333477
dc.descriptionFunder: Gatsby Charitable Foundation; doi: https://doi.org/10.13039/501100000324
dc.description.abstractCrop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/449/2169
dc.subject/631/449/2661/2666
dc.subject/631/449/711
dc.subject/631/208/8
dc.subject/45
dc.subject/45/77
dc.subject/49/23
dc.subjectarticle
dc.titleThe barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics.
dc.typeArticle
dc.date.updated2022-01-31T16:21:57Z
prism.issueIdentifier1
prism.publicationNameNat Commun
prism.volume12
dc.identifier.doi10.17863/CAM.80898
dcterms.dateAccepted2021-11-11
rioxxterms.versionofrecord10.1038/s41467-021-27288-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBettgenhaeuser, Jan [0000-0002-6901-1774]
dc.contributor.orcidHernández-Pinzón, Inmaculada [0000-0003-3711-2893]
dc.contributor.orcidGreen, Phon [0000-0002-1968-0574]
dc.contributor.orcidWaugh, Robbie [0000-0003-1045-3065]
dc.contributor.orcidSteffenson, Brian J [0000-0001-7961-5363]
dc.contributor.orcidWulff, Brande BH [0000-0003-4044-4346]
dc.contributor.orcidDreiseitl, Antonín [0000-0002-9137-3210]
dc.contributor.orcidMoscou, Matthew J [0000-0003-2098-6818]
dc.identifier.eissn2041-1723
pubs.funder-project-idRCUK | Biotechnology and Biological Sciences Research Council (BBSRC) (BB/J004553/1, BB/P012574/1, BBS/E/J/000PR9795)
pubs.funder-project-idHuman Frontier Science Program (HFSP) (LT000218/2011-L)
cam.issuedOnline2021-11-25


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