Signalling dynamics, cell decisions, and homeostatic control in health and disease.
View / Open Files
Publication Date
2022-04Journal Title
Curr Opin Cell Biol
ISSN
0955-0674
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Valls, P. O., & Esposito, A. (2022). Signalling dynamics, cell decisions, and homeostatic control in health and disease.. Curr Opin Cell Biol https://doi.org/10.1016/j.ceb.2022.01.011
Abstract
Cell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, cell signalling is a topic of intense research efforts aimed to elucidate how cells coordinate transitions between states in developing and adult organisms in physiological and pathological conditions. Here, we review current knowledge of how cell signalling operates at multiple spatial and temporal scales, focusing on how single-cell analytical techniques reveal mechanisms underpinning cell-to-cell variability, signalling plasticity, and collective cellular responses.
Sponsorship
A.E. acknowledges the financial support provided by the CRUK with a multi-disciplinary project award (OncoLive, C54674/A27487), pump-priming funds from the CRUK Cambridge Center (C9685/A25117, C9685/A28397). A.E. also acknowledges financial support from Medical Research Council program grants (MC_UU_12022/1 and MC_UU_12022/8) awarded to the MRC Cancer Unit. P.O.V. acknowledges the financial support of the MRC Doctoral Training Award (ref. 1753414) granted to the MRC Cancer Unit.
Funder references
MRC (unknown)
Cancer Research UK (CRUK-)
Cancer Research UK (A25117)
MRC (MC_UU_12022/8)
Medical Research Council (MC_UU_12022/1)
Embargo Lift Date
2023-03-01
Identifiers
External DOI: https://doi.org/10.1016/j.ceb.2022.01.011
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333581
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
Statistics
Total file downloads (since January 2020). For more information on metrics see the
IRUS guide.
Recommended or similar items
The current recommendation prototype on the Apollo Repository will be turned off on 03 February 2023. Although the pilot has been fruitful for both parties, the service provider IKVA is focusing on horizon scanning products and so the recommender service can no longer be supported. We recognise the importance of recommender services in supporting research discovery and are evaluating offerings from other service providers. If you would like to offer feedback on this decision please contact us on: support@repository.cam.ac.uk