Physical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and women.
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Authors
Dempsey, Paddy C
Aadland, Eivind
Kvalheim, Olav M
Lindsay, Tim
Khaw, Kay-Tee
Wareham, Nicholas J
Brage, Søren
Publication Date
2022-03Journal Title
Prev Med
ISSN
0091-7435
Publisher
Elsevier BV
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Dempsey, P. C., Aadland, E., Strain, T., Kvalheim, O. M., Westgate, K., Lindsay, T., Khaw, K., et al. (2022). Physical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and women.. Prev Med https://doi.org/10.1016/j.ypmed.2022.106977
Abstract
Accelerometers provide detailed data about physical activity (PA) across the full intensity spectrum. However, when examining associations with health, results are often aggregated to only a few summary measures [e.g. time spent "sedentary" or "moderate-to-vigorous" intensity PA]. Using multivariate pattern analysis, which can handle collinear exposure variables, we examined associations between the full PA intensity spectrum and cardiometabolic risk (CMR) in a population-based sample of middle-aged to older adults. Participants (n = 3660; mean ± SD age = 69 ± 8y and BMI = 26.7 ± 4.2 kg/m2; 55% female) from the EPIC-Norfolk study (UK) with valid accelerometry (ActiGraph-GT1M) data were included. We used multivariate pattern analysis with partial least squares regression to examine cross-sectional multivariate associations (r) across the full PA intensity spectrum [minutes/day at 0-5000 counts-per-minute (cpm); 5 s epoch] with a continuous CMR score (reflecting waist, blood pressure, lipid, and glucose metabolism). Models were sex-stratified and adjusted for potential confounders. There was a positive (detrimental) association between PA and CMR at 0-12 cpm (maximally-adjusted r = 0.08 (95%CI 0.06-0.10). PA was negatively (favourably) associated with CMR at all intensities above 13 cpm ranging between r = -0.09 (0.07-0.12) at 800-999 cpm and r = -0.14 (0.11-0.16) at 75-99 and 4000-4999 cpm. The strongest favourable associations were from 50 to 800 cpm (r = 0.10-0.12) in men, but from ≥2500 cpm (r = 0.18-0.20) in women; with higher proportions of model explained variance for women (R2 = 7.4% vs. 2.3%). Most of the PA intensity spectrum was beneficially associated with CMR in middle-aged to older adults, even at intensities lower than what has traditionally been considered "sedentary" or "light-intensity" activity. This supports encouragement of PA at almost any intensity in this age-group.
Sponsorship
The EPIC-Norfolk study (DOI 10.22025/2019.10.105.00004) has received funding from the Medical Research Council (MR/N003284/1 and MC_UU_12015/1) and Cancer Research UK (C864/A14136). PCD is supported by a National Health and Medical Research Council of Australia research fellowship (#1142685). PCD, TS, SB, KW and NJW are supported by the UK Medical Research Council [grant numbers MC_UU_00006/4 and MC_UU_12015/3]. TL is supported by the Cambridge Trust and St Catharine’s College. The work of KWe is supported by NIHR Biomedical Research Centre in Cambridge (IS-BRC-1215-20014).
Funder references
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
MRC (MC_UU_00006/4)
Medical Research Council (MC_UU_12015/3)
Medical Research Council (MR/N003284/1)
Medical Research Council (MC_UU_12015/1)
National Institute for Health Research (IS-BRC-1215-20014)
Medical Research Council (G1000143)
Medical Research Council (G0401527)
Embargo Lift Date
2023-02-04
Identifiers
External DOI: https://doi.org/10.1016/j.ypmed.2022.106977
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333673
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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