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dc.contributor.authorZhou, Yin
dc.contributor.authorWalter, Fiona M
dc.contributor.authorMounce, Luke
dc.contributor.authorAbel, Gary A
dc.contributor.authorSingh, Hardeep
dc.contributor.authorHamilton, Willie
dc.contributor.authorStewart, Grant D
dc.contributor.authorLyratzopoulos, Georgios
dc.date.accessioned2022-02-16T00:30:39Z
dc.date.available2022-02-16T00:30:39Z
dc.date.issued2022-01
dc.identifier.issn0960-1643
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334066
dc.description.abstractBACKGROUND: Understanding pre-diagnostic test use could reveal diagnostic windows where more timely evaluation for cancer may be indicated. AIM: To examine pre-diagnostic patterns of results of abnormal blood tests in patients with bladder and renal cancer. DESIGN AND SETTING: A retrospective cohort study using primary care and cancer registry data on patients with bladder and renal cancer who were diagnosed between April 2012 and December 2015 in England. METHOD: The rates of patients with a first abnormal result in the year before cancer diagnosis, for 'generic' (full blood count components, inflammatory markers, and calcium) and 'organ-specific' blood tests (creatinine and liver function test components) that may lead to subsequent detection of incidental cancers, were examined. Poisson regression was used to detect the month during which the cohort's rate of each abnormal test started to increase from baseline. The proportion of patients with a test found in the first half of the diagnostic window was examined, as these 'early' tests might represent opportunities where further evaluation could be initiated. RESULTS: Data from 4533 patients with bladder and renal cancer were analysed. The monthly rate of patients with a first abnormal test increased towards the time of cancer diagnosis. Abnormalities of both generic (for example, high inflammatory markers) and organ-specific tests (for example, high creatinine) started to increase from 6-8 months pre-diagnosis, with 25%-40% of these patients having an abnormal test in the 'early half' of the diagnostic window. CONCLUSION: Population-level signals of bladder and renal cancer can be observed in abnormalities in commonly performed primary care blood tests up to 8 months before diagnosis, indicating the potential for earlier diagnosis in some patients.
dc.format.mediumElectronic-Print
dc.publisherRoyal College of General Practitioners
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectbladder cancer
dc.subjectdiagnostic tests, routine
dc.subjectearly detection of cancer
dc.subjectprimary health care
dc.subjectrenal cancer
dc.subjecttest utilisation
dc.titleIdentifying opportunities for timely diagnosis of bladder and renal cancer via abnormal blood tests: a longitudinal linked data study.
dc.typeArticle
dc.publisher.departmentDepartment of Public Health And Primary Care, The Primary Care Unit
dc.publisher.departmentDepartment of Surgery
dc.date.updated2022-02-15T11:54:31Z
prism.endingPagee25
prism.issueIdentifier714
prism.publicationDate2022
prism.publicationNameBr J Gen Pract
prism.startingPagee19
prism.volume72
dc.identifier.doi10.17863/CAM.81477
dcterms.dateAccepted2021-09-14
rioxxterms.versionofrecord10.3399/BJGP.2021.0282
rioxxterms.versionVoR
dc.contributor.orcidZhou, Yin [0000-0002-8815-1457]
dc.contributor.orcidWalter, Fiona [0000-0002-7191-6476]
dc.contributor.orcidStewart, Grant [0000-0003-3188-9140]
dc.identifier.eissn1478-5242
rioxxterms.typeJournal Article/Review
cam.issuedOnline2021-12-31
cam.depositDate2022-02-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International