To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.
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Publication Date
2022-11Journal Title
Wound Repair Regen
ISSN
1067-1927
Publisher
Wiley
Type
Article
This Version
AM
Metadata
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Aztekin, C., & Storer, M. A. (2022). To regenerate or not to regenerate: Vertebrate model organisms of regeneration-competency and -incompetency.. Wound Repair Regen https://doi.org/10.1111/wrr.13000
Abstract
Why only certain species can regenerate their appendages (e.g. tails and limbs) remains one of the biggest mysteries of nature. Unlike anuran tadpoles and salamanders, humans and other mammals cannot regenerate their limbs, but can only regrow lost digit tips under specific circumstances. Numerous hypotheses have been postulated to explain regeneration-incompetency in mammals. By studying model organisms that show varying regenerative abilities, we now have more opportunities to uncover what contributes to regeneration-incompetency and functionally test which perturbations restore appendage regrowth. Particularly, Xenopus laevis tail and limb, and mouse digit tip model systems exhibit naturally occurring variations in regenerative capacities. Here, we discuss major hypotheses that are suggested to contribute to regeneration-incompetency, and how species with varying regenerative abilities reflect on these hypotheses.
Keywords
CambridgeStemCellInstitute
Sponsorship
Wellcome Trust (203151/Z/16/Z)
Medical Research Council (MC_PC_17230)
Embargo Lift Date
2023-02-22
Identifiers
External DOI: https://doi.org/10.1111/wrr.13000
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334347
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