SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
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Authors
Dejnirattisai, Wanwisa
Huo, Jiandong
Zhou, Daming
Zahradník, Jiří
Supasa, Piyada
Liu, Chang
Duyvesteyn, Helen ME
Ginn, Helen M
Mentzer, Alexander J
Tuekprakhon, Aekkachai
Nutalai, Rungtiwa
Wang, Beibei
Dijokaite, Aiste
Khan, Suman
Avinoam, Ori
Bahar, Mohammad
Skelly, Donal
Adele, Sandra
Johnson, Sile Ann
Amini, Ali
Ritter, Thomas G
Mason, Chris
Dold, Christina
Pan, Daniel
Assadi, Sara
Bellass, Adam
Omo-Dare, Nicola
Koeckerling, David
Flaxman, Amy
Jenkin, Daniel
Aley, Parvinder K
Voysey, Merryn
Costa Clemens, Sue Ann
Naveca, Felipe Gomes
Nascimento, Valdinete
Nascimento, Fernanda
Fernandes da Costa, Cristiano
Resende, Paola Cristina
Pauvolid-Correa, Alex
Siqueira, Marilda M
Baillie, Vicky
Serafin, Natali
Kwatra, Gaurav
Da Silva, Kelly
Madhi, Shabir A
Nunes, Marta C
Malik, Tariq
Openshaw, Peter JM
Baillie, J Kenneth
Semple, Malcolm G
Townsend, Alain R
Huang, Kuan-Ying A
Tan, Tiong Kit
Carroll, Miles W
Klenerman, Paul
Barnes, Eleanor
Dunachie, Susanna J
Constantinides, Bede
Webster, Hermione
Crook, Derrick
Pollard, Andrew J
Lambe, Teresa
OPTIC Consortium
ISARIC4C Consortium
Paterson, Neil G
Williams, Mark A
Hall, David R
Fry, Elizabeth E
Mongkolsapaya, Juthathip
Ren, Jingshan
Schreiber, Gideon
Stuart, David I
Screaton, Gavin R
Publication Date
2022-02-03Journal Title
Cell
ISSN
0092-8674
Publisher
Elsevier BV
Volume
185
Issue
3
Pages
467-484.e15
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., Duyvesteyn, H. M., et al. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185 (3), 467-484.e15. https://doi.org/10.1016/j.cell.2021.12.046
Abstract
On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
Keywords
Omicron, RBD, SARS-CoV-2, Spike, immune evasion, receptor interaction, vaccines, variants
Sponsorship
Medical Research Council (MR/P011705/1)
Identifiers
External DOI: https://doi.org/10.1016/j.cell.2021.12.046
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334439
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