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dc.contributor.authorDejnirattisai, Wanwisa
dc.contributor.authorHuo, Jiandong
dc.contributor.authorZhou, Daming
dc.contributor.authorZahradník, Jiří
dc.contributor.authorSupasa, Piyada
dc.contributor.authorLiu, Chang
dc.contributor.authorDuyvesteyn, Helen ME
dc.contributor.authorGinn, Helen M
dc.contributor.authorMentzer, Alexander J
dc.contributor.authorTuekprakhon, Aekkachai
dc.contributor.authorNutalai, Rungtiwa
dc.contributor.authorWang, Beibei
dc.contributor.authorDijokaite, Aiste
dc.contributor.authorKhan, Suman
dc.contributor.authorAvinoam, Ori
dc.contributor.authorBahar, Mohammad
dc.contributor.authorSkelly, Donal
dc.contributor.authorAdele, Sandra
dc.contributor.authorJohnson, Sile Ann
dc.contributor.authorAmini, Ali
dc.contributor.authorRitter, Thomas G
dc.contributor.authorMason, Chris
dc.contributor.authorDold, Christina
dc.contributor.authorPan, Daniel
dc.contributor.authorAssadi, Sara
dc.contributor.authorBellass, Adam
dc.contributor.authorOmo-Dare, Nicola
dc.contributor.authorKoeckerling, David
dc.contributor.authorFlaxman, Amy
dc.contributor.authorJenkin, Daniel
dc.contributor.authorAley, Parvinder K
dc.contributor.authorVoysey, Merryn
dc.contributor.authorCosta Clemens, Sue Ann
dc.contributor.authorNaveca, Felipe Gomes
dc.contributor.authorNascimento, Valdinete
dc.contributor.authorNascimento, Fernanda
dc.contributor.authorFernandes da Costa, Cristiano
dc.contributor.authorResende, Paola Cristina
dc.contributor.authorPauvolid-Correa, Alex
dc.contributor.authorSiqueira, Marilda M
dc.contributor.authorBaillie, Vicky
dc.contributor.authorSerafin, Natali
dc.contributor.authorKwatra, Gaurav
dc.contributor.authorDa Silva, Kelly
dc.contributor.authorMadhi, Shabir A
dc.contributor.authorNunes, Marta C
dc.contributor.authorMalik, Tariq
dc.contributor.authorOpenshaw, Peter JM
dc.contributor.authorBaillie, J Kenneth
dc.contributor.authorSemple, Malcolm G
dc.contributor.authorTownsend, Alain R
dc.contributor.authorHuang, Kuan-Ying A
dc.contributor.authorTan, Tiong Kit
dc.contributor.authorCarroll, Miles W
dc.contributor.authorKlenerman, Paul
dc.contributor.authorBarnes, Eleanor
dc.contributor.authorDunachie, Susanna J
dc.contributor.authorConstantinides, Bede
dc.contributor.authorWebster, Hermione
dc.contributor.authorCrook, Derrick
dc.contributor.authorPollard, Andrew J
dc.contributor.authorLambe, Teresa
dc.contributor.authorOPTIC Consortium
dc.contributor.authorISARIC4C Consortium
dc.contributor.authorPaterson, Neil G
dc.contributor.authorWilliams, Mark A
dc.contributor.authorHall, David R
dc.contributor.authorFry, Elizabeth E
dc.contributor.authorMongkolsapaya, Juthathip
dc.contributor.authorRen, Jingshan
dc.contributor.authorSchreiber, Gideon
dc.contributor.authorStuart, David I
dc.contributor.authorScreaton, Gavin R
dc.date.accessioned2022-02-25T00:30:05Z
dc.date.available2022-02-25T00:30:05Z
dc.date.issued2022-02-03
dc.identifier.issn0092-8674
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/334439
dc.description.abstractOn 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic Alpha, Beta, Gamma, or Delta are substantially reduced, or the sera failed to neutralize. Titers against Omicron are boosted by third vaccine doses and are high in both vaccinated individuals and those infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of the large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses and uses mutations that confer tight binding to ACE2 to unleash evolution driven by immune escape. This leads to a large number of mutations in the ACE2 binding site and rebalances receptor affinity to that of earlier pandemic viruses.
dc.format.mediumPrint-Electronic
dc.publisherElsevier BV
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectOmicron
dc.subjectRBD
dc.subjectSARS-CoV-2
dc.subjectSpike
dc.subjectimmune evasion
dc.subjectreceptor interaction
dc.subjectvaccines
dc.subjectvariants
dc.titleSARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
dc.typeArticle
dc.date.updated2022-02-23T11:52:37Z
prism.endingPage484.e15
prism.issueIdentifier3
prism.publicationDate2022
prism.publicationNameCell
prism.startingPage467
prism.volume185
dc.identifier.doi10.17863/CAM.81854
dcterms.dateAccepted2021-12-29
rioxxterms.versionofrecord10.1016/j.cell.2021.12.046
rioxxterms.versionVoR
dc.identifier.eissn1097-4172
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/P011705/1)
cam.depositDate2022-02-23
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International