Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.
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Authors
Gutiérrez Rodelo, Citlaly
Salinas, Rafael A
Armenta JaimeArmenta, Erika
Armenta, Silvia
Galdámez-Martínez, Andrés
Castillo-Blum, Silvia E
Astudillo-de la Vega, Horacio
Nirmala Grace, Andrews
Aguilar-Salinas, Carlos A
Gutiérrez Rodelo, Juliana
Alsanie, Walaa F
Santana, Guillermo
Thakur, Vijay Kumar
Dutt, Ateet
Publication Date
2022-04-15Journal Title
Coord Chem Rev
ISSN
0010-8545
Publisher
Elsevier BV
Volume
457
Number
214402
Pages
214402
Type
Article
This Version
VoR
Physical Medium
Print-Electronic
Metadata
Show full item recordCitation
Gutiérrez Rodelo, C., Salinas, R. A., Armenta JaimeArmenta, E., Armenta, S., Galdámez-Martínez, A., Castillo-Blum, S. E., Astudillo-de la Vega, H., et al. (2022). Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials.. Coord Chem Rev, 457 (214402), 214402. https://doi.org/10.1016/j.ccr.2021.214402
Abstract
Respiratory viruses represent a severe public health risk worldwide, and the research contribution to tackle the current pandemic caused by the SARS-CoV-2 is one of the main targets among the scientific community. In this regard, experts from different fields have gathered to confront this catastrophic pandemic. This review illustrates how nanotechnology intervention could be valuable in solving this difficult situation, and the state of the art of Zn-based nanostructures are discussed in detail. For virus detection, learning from the experience of other respiratory viruses such as influenza, the potential use of Zn nanomaterials as suitable sensing platforms to recognize the S1 spike protein in SARS-CoV-2 are shown. Furthermore, a discussion about the antiviral mechanisms reported for ZnO nanostructures is included, which can help develop surface disinfectants and protective coatings. At the same time, the properties of Zn-based materials as supplements for reducing viral activity and the recovery of infected patients are illustrated. Within the scope of noble adjuvants to improve the immune response, the ZnO NPs properties as immunomodulators are explained, and potential prototypes of nanoengineered particles with metallic cations (like Zn2+) are suggested. Therefore, using Zn-associated nanomaterials from detection to disinfection, supplementation, and immunomodulation opens a wide area of opportunities to combat these emerging respiratory viruses. Finally, the attractive properties of these nanomaterials can be extrapolated to new clinical challenges.
Keywords
Biosensors, COVID-19, Detection and diagnosis, Nanomaterials, Prophylaxis, Respiratory viruses, Zn
Identifiers
External DOI: https://doi.org/10.1016/j.ccr.2021.214402
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335316
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