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dc.contributor.authorSonkusare, Saurabh
dc.contributor.authorDing, Qiong
dc.contributor.authorZhang, Yingying
dc.contributor.authorWang, Linbin
dc.contributor.authorGong, Hengfen
dc.contributor.authorMandali, Alekhya
dc.contributor.authorManssuer, Luis
dc.contributor.authorZhao, Yi-Jie
dc.contributor.authorPan, Yixin
dc.contributor.authorZhang, Chencheng
dc.contributor.authorLi, Dianyou
dc.contributor.authorSun, Bomin
dc.contributor.authorVoon, Valerie
dc.date.accessioned2022-03-28T19:06:31Z
dc.date.available2022-03-28T19:06:31Z
dc.date.issued2022-02-22
dc.identifier.issn2158-3188
dc.identifier.other35194027
dc.identifier.otherPMC8863838
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335415
dc.description.abstractThe habenula is an epithalamic structure implicated in negative reward mechanisms and plays a downstream modulatory role in regulation of dopaminergic and serotonergic functions. Human and animal studies show its hyperactivity in depression which is curtailed by the antidepressant response of ketamine. Deep brain stimulation of habenula (DBS) for major depression have also shown promising results. However, direct neuronal activity of habenula in human studies have rarely been reported. Here, in a cross-sectional design, we acquired both spontaneous resting state and emotional task-induced neuronal recordings from habenula from treatment resistant depressed patients undergoing DBS surgery. We first characterise the aperiodic component (1/f slope) of the power spectrum, interpreted to signify excitation-inhibition balance, in resting and task state. This aperiodicity for left habenula correlated between rest and task and which was significantly positively correlated with depression severity. Time-frequency responses to the emotional picture viewing task show condition differences in beta and gamma frequencies for left habenula and alpha for right habenula. Notably, alpha activity for right habenula was negatively correlated with depression severity. Overall, from direct habenular recordings, we thus show findings convergent with depression models of aberrant excitatory glutamatergic output of the habenula driving inhibition of monoaminergic systems.
dc.description.sponsorshipMedical Research Council Senior Clinical Fellowship (MR/P008747/1)
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2158-3188
dc.sourcenlmid: 101562664
dc.titlePower signatures of habenular neuronal signals in patients with bipolar or unipolar depressive disorders correlate with their disease severity.
dc.typeArticle
dc.date.updated2022-03-28T19:06:30Z
prism.issueIdentifier1
prism.publicationNameTransl Psychiatry
prism.volume12
dc.identifier.doi10.17863/CAM.82844
dcterms.dateAccepted2022-01-28
rioxxterms.versionofrecord10.1038/s41398-022-01830-3
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidSonkusare, Saurabh [0000-0002-4439-0579]
dc.contributor.orcidZhang, Yingying [0000-0002-0408-1632]
dc.contributor.orcidZhang, Chencheng [0000-0003-4472-4134]
dc.contributor.orcidSun, Bomin [0000-0001-5931-2197]
dc.contributor.orcidVoon, Valerie [0000-0001-6790-1776]
dc.identifier.eissn2158-3188
pubs.funder-project-idMedical Research Council (MR/P008747/1)
cam.issuedOnline2022-02-22


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International