Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study.
Authors
Tripoli, Giada
Quattrone, Diego
La Cascia, Caterina
La Barbera, Daniele
Sartorio, Crocettarachele
Seminerio, Fabio
Rodriguez, Victoria
Tarricone, Ilaria
Berardi, Domenico
Arango, Celso
Tortelli, Andrea
Llorca, Pierre-Michel
de Haan, Lieuwe
Velthorst, Eva
Bobes, Julio
Bernardo, Miquel
Sanjuán, Julio
Luis Santos, Jose
Arrojo, Manuel
Marta Del-Ben, Cristina
Rossi Menezes, Paulo
van der Ven, Els
Jones, Peter B
Jongsma, Hannah E
Tosato, Sarah
O'Donovan, Michael
Rutten, Bart PF
van Os, Jim
Morgan, Craig
Sham, Pak C
Di Forti, Marta
Murray, Robin M
Murray, Graham K
Publication Date
2022-09-01Journal Title
Schizophr Bull
ISSN
0586-7614
Publisher
Oxford University Press (OUP)
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Tripoli, G., Quattrone, D., Ferraro, L., Gayer-Anderson, C., La Cascia, C., La Barbera, D., Sartorio, C., et al. (2022). Facial Emotion Recognition in Psychosis and Associations With Polygenic Risk for Schizophrenia: Findings From the Multi-Center EU-GEI Case-Control Study.. Schizophr Bull https://doi.org/10.1093/schbul/sbac022
Abstract
BACKGROUND AND HYPOTHESIS: Facial Emotion Recognition is a key domain of social cognition associated with psychotic disorders as a candidate intermediate phenotype. In this study, we set out to investigate global and specific facial emotion recognition deficits in first-episode psychosis, and whether polygenic liability to psychotic disorders is associated with facial emotion recognition. STUDY DESIGN: 828 First Episode Psychosis (FEP) patients and 1308 population-based controls completed assessments of the Degraded Facial Affect Recognition Task (DFAR) and a subsample of 524 FEP and 899 controls provided blood or saliva samples from which we extracted DNA, performed genotyping and computed polygenic risk scores for schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MD). STUDY RESULTS: A worse ability to globally recognize facial emotion expressions was found in patients compared with controls [B= -1.5 (0.6), 95% CI -2.7 to -0.3], with evidence for stronger effects on negative emotions (fear [B = -3.3 (1.1), 95% CI -5.3 to -1.2] and anger [B = -2.3 (1.1), 95% CI -4.6 to -0.1]) than on happiness [B = 0.3 (0.7), 95% CI -1 to 1.7]. Pooling all participants, and controlling for confounds including case/control status, facial anger recognition was associated significantly with Schizophrenia Polygenic Risk Score (SZ PRS) [B = -3.5 (1.7), 95% CI -6.9 to -0.2]. CONCLUSIONS: Psychosis is associated with impaired recognition of fear and anger, and higher SZ PRS is associated with worse facial anger recognition. Our findings provide evidence that facial emotion recognition of anger might play a role as an intermediate phenotype for psychosis.
Embargo Lift Date
2023-03-23
Identifiers
External DOI: https://doi.org/10.1093/schbul/sbac022
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335462
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