Genetic variation of macronutrient tolerance in Drosophila melanogaster.
dc.contributor.author | Havula, E | |
dc.contributor.author | Ghazanfar, S | |
dc.contributor.author | Lamichane, N | |
dc.contributor.author | Francis, D | |
dc.contributor.author | Hasygar, K | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Alton, LA | |
dc.contributor.author | Johnstone, J | |
dc.contributor.author | Needham, EJ | |
dc.contributor.author | Pulpitel, T | |
dc.contributor.author | Clark, T | |
dc.contributor.author | Niranjan, HN | |
dc.contributor.author | Shang, V | |
dc.contributor.author | Tong, V | |
dc.contributor.author | Jiwnani, N | |
dc.contributor.author | Audia, G | |
dc.contributor.author | Alves, AN | |
dc.contributor.author | Sylow, L | |
dc.contributor.author | Mirth, C | |
dc.contributor.author | Neely, GG | |
dc.contributor.author | Yang, J | |
dc.contributor.author | Hietakangas, V | |
dc.contributor.author | Simpson, SJ | |
dc.contributor.author | Senior, AM | |
dc.date.accessioned | 2022-03-31T15:12:59Z | |
dc.date.available | 2022-03-31T15:12:59Z | |
dc.date.issued | 2022-03-28 | |
dc.date.submitted | 2021-04-07 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.other | s41467-022-29183-x | |
dc.identifier.other | 29183 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/335551 | |
dc.description.abstract | Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition. | |
dc.language | en | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Article | |
dc.subject | /631/80/86 | |
dc.subject | /631/208/191 | |
dc.subject | /631/443/319 | |
dc.subject | /38 | |
dc.subject | /13 | |
dc.subject | /38/43 | |
dc.subject | /64/24 | |
dc.subject | article | |
dc.title | Genetic variation of macronutrient tolerance in Drosophila melanogaster. | |
dc.type | Article | |
dc.date.updated | 2022-03-31T15:12:58Z | |
prism.issueIdentifier | 1 | |
prism.publicationName | Nat Commun | |
prism.volume | 13 | |
dc.identifier.doi | 10.17863/CAM.82982 | |
dcterms.dateAccepted | 2022-02-28 | |
rioxxterms.versionofrecord | 10.1038/s41467-022-29183-x | |
rioxxterms.version | VoR | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.contributor.orcid | Havula, E [0000-0002-9253-5816] | |
dc.contributor.orcid | Lamichane, N [0000-0002-1746-0332] | |
dc.contributor.orcid | Francis, D [0000-0002-4158-1521] | |
dc.contributor.orcid | Liu, Y [0000-0002-6419-1980] | |
dc.contributor.orcid | Alton, LA [0000-0002-4236-2494] | |
dc.contributor.orcid | Johnstone, J [0000-0002-8523-9269] | |
dc.contributor.orcid | Needham, EJ [0000-0001-6326-9048] | |
dc.contributor.orcid | Jiwnani, N [0000-0001-7308-7109] | |
dc.contributor.orcid | Audia, G [0000-0002-8957-2536] | |
dc.contributor.orcid | Alves, AN [0000-0002-1650-8058] | |
dc.contributor.orcid | Sylow, L [0000-0003-0905-5932] | |
dc.contributor.orcid | Mirth, C [0000-0002-9765-4021] | |
dc.contributor.orcid | Neely, GG [0000-0002-1957-9732] | |
dc.contributor.orcid | Yang, J [0000-0002-5271-2603] | |
dc.contributor.orcid | Hietakangas, V [0000-0002-9900-7549] | |
dc.contributor.orcid | Simpson, SJ [0000-0003-0256-7687] | |
dc.contributor.orcid | Senior, AM [0000-0001-9805-7280] | |
dc.identifier.eissn | 2041-1723 | |
cam.issuedOnline | 2022-03-28 |
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