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dc.contributor.authorLi, Zhenfeng
dc.contributor.authorLuo, Tao
dc.contributor.authorWang, Shuo
dc.contributor.authorJia, Heyue
dc.contributor.authorGong, Qi
dc.contributor.authorLiu, Xiaoping
dc.contributor.authorSutcliffe, Michael
dc.contributor.authorZhu, Haijing
dc.contributor.authorChen, Duanduan
dc.contributor.authorXiong, Jiang
dc.contributor.authorTeng, Zhongzhao
dc.date.accessioned2022-04-01T09:33:13Z
dc.date.available2022-04-01T09:33:13Z
dc.date.issued2022-07-01
dc.identifier.issn1742-7061
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/335661
dc.description.abstractAims: This study investigated the association between the macroscopic mechanical response of aortic dissection (AoD) flap, its fibre features, and patient physiological features and clinical presentations. Methods: Uniaxial test was performed with tissue strips in both circumferential and longitudinal directions from 35 patients with (AoD:CC) and without (AoD:w/oCC) cerebral/coronary complications, and 19 patients with rheumatic or valve-related heart diseases (RH). A Bayesian inference framework was used to estimate the expectation of material constants (C1, D1, and D2) of the modified Mooney-Rivlin strain energy density function. Histological examination was used to visualise the elastin and collagen in the tissue strips and image processing was performed to quantify their area percentages, fibre misalignment and waviness. Results: The elastin area percentage was negatively associated with age (p=0.008), while collagen increased about 6% from age 40 to 70 (p=0.03). Elastin fibre was less dispersed and wavier in old patients and no significant association was found between patient age and collagen fibre dispersion or waviness. Features of fibrous microstructures, either elastin or collagen, were comparable between AoD:CC and AoD:w/oCC group. Elastin and collagen area percentages were positively correlated with C1 and D2, respectively, while the elastin and collagen waviness were negatively correlated with C1 and D2, respectively. Elastin dispersion was negatively correlated to D2. Multivariate analysis showed that D2 was an effective parameter which could differentiate patient groups with different age and clinical presentations, as well as the direction of tissue strip. Conclusion: Fibre dispersion and waviness in the aortic dissection flap changed with patient age and clinical presentations, and these can be captured by the material constants in the strain energy density function.
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleMechanical and Histological Characteristics of Aortic Dissection Tissues
dc.typeArticle
dc.publisher.departmentDepartment of Engineering
dc.date.updated2022-03-25T12:13:15Z
prism.publicationNameActa Biomaterialia
dc.identifier.doi10.17863/CAM.83092
dcterms.dateAccepted2022-03-24
rioxxterms.versionofrecord10.1016/j.actbio.2022.03.042
rioxxterms.versionAM
dc.contributor.orcidSutcliffe, Michael [0000-0001-9729-4460]
dc.identifier.eissn1878-7568
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-03-30
cam.orpheus.successTue Apr 12 08:22:51 BST 2022 - Embargo updated
cam.depositDate2022-03-25
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-03-30


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International