Mechanical and Histological Characteristics of Aortic Dissection Tissues
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Authors
Li, Zhenfeng
Luo, Tao
Wang, Shuo
Jia, Heyue
Gong, Qi
Liu, Xiaoping
Zhu, Haijing
Chen, Duanduan
Xiong, Jiang
Teng, Zhongzhao
Publication Date
2022-07-01Journal Title
Acta Biomaterialia
ISSN
1742-7061
Publisher
Elsevier
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Li, Z., Luo, T., Wang, S., Jia, H., Gong, Q., Liu, X., Sutcliffe, M., et al. (2022). Mechanical and Histological Characteristics of Aortic Dissection Tissues. Acta Biomaterialia https://doi.org/10.1016/j.actbio.2022.03.042
Abstract
Aims: This study investigated the association between the macroscopic mechanical response of aortic dissection (AoD) flap, its fibre features, and patient physiological features and clinical presentations.
Methods: Uniaxial test was performed with tissue strips in both circumferential and longitudinal directions from 35 patients with (AoD:CC) and without (AoD:w/oCC) cerebral/coronary complications, and 19 patients with rheumatic or valve-related heart diseases (RH). A Bayesian inference framework was used to estimate the expectation of material constants (C1, D1, and D2) of the modified Mooney-Rivlin strain energy density function. Histological examination was used to visualise the elastin and collagen in the tissue strips and image processing was performed to quantify their area percentages, fibre misalignment and waviness.
Results: The elastin area percentage was negatively associated with age (p=0.008), while collagen increased about 6% from age 40 to 70 (p=0.03). Elastin fibre was less dispersed and wavier in old patients and no significant association was found between patient age and collagen fibre dispersion or waviness. Features of fibrous microstructures, either elastin or collagen, were comparable between AoD:CC and AoD:w/oCC group. Elastin and collagen area percentages were positively correlated with C1 and D2, respectively, while the elastin and collagen waviness were negatively correlated with C1 and D2, respectively. Elastin dispersion was negatively correlated to D2. Multivariate analysis showed that D2 was an effective parameter which could differentiate patient groups with different age and clinical presentations, as well as the direction of tissue strip.
Conclusion: Fibre dispersion and waviness in the aortic dissection flap changed with patient age and clinical presentations, and these can be captured by the material constants in the strain energy density function.
Embargo Lift Date
2023-03-30
Identifiers
External DOI: https://doi.org/10.1016/j.actbio.2022.03.042
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335661
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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