Humoral immunity at the brain borders in homeostasis.
Posner, David A
Lee, Colin Yc
Clatworthy, Menna R
Curr Opin Immunol
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Posner, D. A., Lee, C. Y., Portet, A., & Clatworthy, M. R. (2022). Humoral immunity at the brain borders in homeostasis.. Curr Opin Immunol https://doi.org/10.1016/j.coi.2022.102188
The meninges encase the brain and spinal cord and house a variety of immune cells, including developing and mature B cells, and antibody-secreting plasma cells. In homeostasis, these cells localize around the dural venous sinuses, providing a defense 'zone' to protect the brain and spinal cord from blood-borne pathogens. Dural plasma cells predominantly secrete IgA antibodies, and some originate from the gastrointestinal tract, with the number and antibody isotype shaped by the gut microbiome. For developing B cells arriving from the adjacent bone marrow, the dura provides a site to tolerize against central nervous system antigens. In this review, we will discuss our current understanding of meningeal humoral immunity in homeostasis.
DP is supported by a National Council of Science and Technology (CONACyT) of Mexico and Cambridge Trust PhD scholarship and CYCL by a Gates Scholarship. MRC was/is supported by a Wellcome Investigator Grant (220268/Z/20/Z), a Medical Research Council Research Project Grant (MR/S035842/1), a National Institute of Health Research (NIHR) Research Professorship RP-2017-08-ST2-002, and MRC and AP by the NIHR Cambridge Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Wellcome Trust (220268/Z/20/Z)
Medical Research Council (MR/S035842/1)
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External DOI: https://doi.org/10.1016/j.coi.2022.102188
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335847
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/