Humoral immunity at the brain borders in homeostasis.
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Publication Date
2022-05-12Journal Title
Curr Opin Immunol
ISSN
0952-7915
Publisher
Elsevier
Type
Article
This Version
AM
Metadata
Show full item recordCitation
Posner, D., Lee, C. Y., Portet, A., & Clatworthy, M. (2022). Humoral immunity at the brain borders in homeostasis.. Curr Opin Immunol https://doi.org/10.1016/j.coi.2022.102188
Abstract
The meninges encase the brain and spinal cord and house a variety of immune cells, including developing and mature B cells, and antibody-secreting plasma cells. In homeostasis, these cells localize around the dural venous sinuses, providing a defense 'zone' to protect the brain and spinal cord from blood-borne pathogens. Dural plasma cells predominantly secrete IgA antibodies, and some originate from the gastrointestinal tract, with the number and antibody isotype shaped by the gut microbiome. For developing B cells arriving from the adjacent bone marrow, the dura provides a site to tolerize against central nervous system antigens. In this review, we will discuss our current understanding of meningeal humoral immunity in homeostasis.
Sponsorship
DP is supported by a National Council of Science and Technology (CONACyT) of Mexico and Cambridge Trust PhD scholarship and CYCL by a Gates Scholarship. MRC was/is supported by a Wellcome Investigator Grant (220268/Z/20/Z), a Medical Research Council Research Project Grant
(MR/S035842/1), a National Institute of Health Research (NIHR) Research Professorship RP-2017-08-ST2-002, and MRC and AP by the NIHR Cambridge Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Funder references
Wellcome Trust (220268/Z/20/Z)
Medical Research Council (MR/S035842/1)
Embargo Lift Date
2025-04-06
Identifiers
External DOI: https://doi.org/10.1016/j.coi.2022.102188
This record's URL: https://www.repository.cam.ac.uk/handle/1810/335847
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International
Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/
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