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dc.contributor.authorFortuin-de Smidt, Melony C
dc.contributor.authorSewe, Maquins Odhiambo
dc.contributor.authorLassale, Camille
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAndersson, Jonas
dc.contributor.authorHuerta, José María
dc.contributor.authorEkelund, Ulf
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorTong, Tammy YN
dc.contributor.authorDahm, Christina C
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorSteindorf, Karen
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorKatzke, Verena
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorMasala, Giovanna
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBoer, Jolanda MA
dc.contributor.authorOnland-Moret, N Charlotte
dc.contributor.authorWendel-Vos, GC Wanda
dc.contributor.authorvan der Schouw, Yvonne T
dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorAgudo, Antonio
dc.contributor.authorPetrova, Dafina
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorConchi, Moreno-Iribas
dc.contributor.authorAmiano, Pilar
dc.contributor.authorMelander, Olle
dc.contributor.authorHeath, Alicia K
dc.contributor.authorAune, Dagfinn
dc.contributor.authorForouhi, Nita
dc.contributor.authorLangenberg, Claudia
dc.contributor.authorBrage, Soren
dc.contributor.authorRiboli, Elio
dc.contributor.authorWareham, Nicholas
dc.contributor.authorDanesh, John
dc.contributor.authorButterworth, Adam
dc.contributor.authorWennberg, Patrik
dc.date.accessioned2022-04-14T23:30:53Z
dc.date.available2022-04-14T23:30:53Z
dc.date.issued2022-04-11
dc.identifier.issn2047-4873
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336121
dc.description.abstractThis study aimed to evaluate the association between physical activity and the incidence of coronary heart disease (CHD) in individuals with and without CHD risk factors. EPIC-CVD is a case-cohort study of 29 333 participants that included 13 582 incident CHD cases and a randomly selected sub-cohort nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Self-reported physical activity was summarized using the Cambridge physical activity index (inactive, moderately inactive, moderately active, and active). Participants were categorized into sub-groups based on the presence or the absence of the following risk factors: obesity (body mass index ≥30 kg/m2 ), hypercholesterolaemia (total cholesterol ≥6.2 mmol/L), history of diabetes, hypertension (self-reported or ≥140/90 mmHg), and current smoking. Prentice-weighted Cox regression was used to assess the association between physical activity and incident CHD events (non-fatal and fatal). Compared to inactive participants without the respective CHD risk factor (referent), excess CHD risk was highest in physically inactive and lowest in moderately active participants with CHD risk factors. Corresponding excess CHD risk estimates amongst those with obesity were 47% [95% confidence interval (CI) 32–64%] and 21% (95%CI 2–44%), with hypercholesterolaemia were 80% (95%CI 55–108%) and 48% (95%CI 22–81%), with hypertension were 80% (95%CI 65– 96%) and 49% (95%CI 28–74%), with diabetes were 142% (95%CI 63–260%), and 100% (95%CI 32–204%), and amongst smokers were 152% (95%CI 122–186%) and 109% (95%CI 74–150%). In people with CHD risk factors, moderate physical activity, equivalent to 40 mins of walking per day, attenuates but does not completely offset CHD risk
dc.publisherOxford University Press (OUP)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePhysical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study
dc.typeArticle
dc.publisher.departmentDepartment of Public Health And Primary Care
dc.publisher.departmentoffice of The School of Clinical Medicine
dc.date.updated2022-04-14T10:59:23Z
prism.publicationNameEuropean Journal of Preventive Cardiology
dc.identifier.doi10.17863/CAM.83546
dcterms.dateAccepted2022-03-10
rioxxterms.versionofrecord10.1093/eurjpc/zwac055
rioxxterms.versionVoR
dc.contributor.orcidForouhi, Nita [0000-0002-5041-248X]
dc.contributor.orcidLangenberg, Claudia [0000-0002-5017-7344]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidDanesh, John [0000-0003-1158-6791]
dc.contributor.orcidButterworth, Adam [0000-0002-6915-9015]
dc.identifier.eissn2047-4881
rioxxterms.typeJournal Article/Review
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idMRC (MC_UU_00006/1)
pubs.funder-project-idMRC (MC_UU_00006/3)
pubs.funder-project-idEuropean Commission (602068)
pubs.funder-project-idMRC (MC_UU_00006/4)
cam.issuedOnline2022-04-11
cam.depositDate2022-04-14
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International