Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy.
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Authors
McLean, Mary A
Gill, Andrew B
Crawford, Robin AF
Latimer, John
Baldwin, Peter
Earl, Helena M
Parkinson, Christine A
Smith, Sarah
Hodgkin, Charlotte
Jimenez-Linan, Mercedes
Brodie, Cara R
Patterson, Ilse
Addley, Helen C
Freeman, Susan J
Moyle, Penelope M
Graves, Martin J
Sala, Evis
Brenton, James D
Gallagher, Ferdia A
Publication Date
2022Journal Title
BJR Open
ISSN
2513-9878
Publisher
British Institute of Radiology
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Deen, S. S., McLean, M. A., Gill, A. B., Crawford, R. A., Latimer, J., Baldwin, P., Earl, H. M., et al. (2022). Magnetization transfer imaging of ovarian cancer: initial experiences of correlation with tissue cellularity and changes following neoadjuvant chemotherapy.. BJR Open https://doi.org/10.1259/bjro.20210078
Abstract
Objectives: To investigate the relationship between magnetization transfer (MT) imaging and tissue macromolecules in high-grade serous ovarian cancer (HGSOC) and whether MT ratio (MTR) changes following neoadjuvant chemotherapy (NACT). Methods: This was a prospective observational study. 12 HGSOC patients were imaged before treatment. MTR was compared to quantified tissue histology and immunohistochemistry. For a subset of patients (n = 5), MT imaging was repeated after NACT. The Shapiro-Wilk test was used to assess for normality of data and Spearman's rank-order or Pearson's correlation tests were then used to compare MTR with tissue quantifications. The Wilcoxon signed-rank test was used to assess for changes in MTR after treatment. Results: Treatment-naïve tumour MTR was 21.9 ± 3.1% (mean ± S.D.). MTR had a positive correlation with cellularity, rho = 0.56 (p < 0.05) and a negative correlation with tumour volume, ρ = -0.72 (p = 0.01). MTR did not correlate with the extracellular proteins, collagen IV or laminin (p = 0.40 and p = 0.90). For those patients imaged before and after NACT, an increase in MTR was observed in each case with mean MTR 20.6 ± 3.1% (median 21.1) pre-treatment and 25.6 ± 3.4% (median 26.5) post-treatment (p = 0.06). Conclusion: In treatment-naïve HGSOC, MTR is associated with cellularity, possibly reflecting intracellular macromolecular concentration. MT may also detect the HGSOC response to NACT, however larger studies are required to validate this finding. Advances in knowledge: MTR in HGSOC is influenced by cellularity. This may be applied to assess for cell changes following treatment.
Identifiers
External DOI: https://doi.org/10.1259/bjro.20210078
This record's URL: https://www.repository.cam.ac.uk/handle/1810/336243
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