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dc.contributor.authorPellino, Gianluca
dc.contributor.authorFuschillo, Giacomo
dc.contributor.authorSimillis, Costantinos
dc.contributor.authorSelvaggi, Lucio
dc.contributor.authorSignoriello, Giuseppe
dc.contributor.authorVinci, Danilo
dc.contributor.authorKontovounisios, Christos
dc.contributor.authorSelvaggi, Francesco
dc.contributor.authorSciaudone, Guido
dc.date.accessioned2022-05-10T01:01:58Z
dc.date.available2022-05-10T01:01:58Z
dc.date.issued2022-03-08
dc.identifier.issn2474-9842
dc.identifier.other35390136
dc.identifier.otherPMC8989040
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/336964
dc.description.abstractBACKGROUND: External rectal prolapse (ERP) is a debilitating condition in which surgery plays an important role. The aim of this study was to evaluate the outcomes of abdominal approaches (AA) and perineal approaches (PA) to ERP. METHODS: This was a PRISMA-compliant systematic review with meta-analysis. Studies published between 1990 and 2021 were retrieved. The primary endpoint was recurrence at the last available follow-up. Secondary endpoints included factors associated with recurrence and function. All studies were assessed for bias using the Newcastle-Ottawa Scale and Cochrane tool. RESULTS: Fifteen studies involving 1611 patients (AA = 817; PA = 794) treated for ERP were included, three of which were randomized controlled trials (RCTs; 114 patients (AA = 54; PA = 60)). Duration of follow-up ranged from 12 to 82 months. Recurrence in non-randomized studies was 7.7 per cent in AA versus 20.1 per cent in PA (odds ratio (OR) 0.29, 95 per cent confidence interval (c.i.) 0.17 to 0.50; P < 0.001, I2 = 45 per cent). In RCTs, there was no significant difference (9.8 per cent versus 16.3 per cent, AA versus PA (OR 0.82, 95 per cent c.i. 0.29 to 2.37; P = 0.72, I2 = 0.0 per cent)). Age at surgery and duration of follow-up were risk factors for recurrence. Following AA, the recurrence rates were 10.1 per cent and 6.2 per cent in patients aged 65 years and older and less than 65 years of age, respectively (effect size [e.s.] 7.7, 95 per cent c.i. 4.5 to 11.5). Following PA, rates were 27 per cent and 16.3 per cent (e.s. 20.1, 95 per cent c.i. 13 to 28.2). Extending follow-up to at least 40 months increased the likelihood of recurrence. The median duration of hospital stay was 4.9 days after PA versus 7.2 days after AA. Overall, incontinence was less likely after AA (OR 0.32), but constipation occurred more frequently (OR 1.68). Most studies were retrospective, and several outcomes from RCTs were not consistent with those observed in non-RCTs. CONCLUSION: The overall risk of recurrence of ERP appears to be higher with PA versus AA. Incontinence is less frequent after AA but at the cost of increased constipation. Age at surgery and duration of follow-up are associated with increased risk of recurrence, which warrants adequate reporting of future studies on this topic.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101722685
dc.sourceessn: 2474-9842
dc.subjectHumans
dc.subjectRectal Prolapse
dc.subjectConstipation
dc.subjectLength of Stay
dc.subjectRetrospective Studies
dc.subjectRandomized Controlled Trials as Topic
dc.titleAbdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis.
dc.typeArticle
dc.date.updated2022-05-10T01:01:57Z
prism.issueIdentifier2
prism.publicationNameBJS Open
prism.volume6
dc.identifier.doi10.17863/CAM.84387
dcterms.dateAccepted2022-01-25
rioxxterms.versionofrecord10.1093/bjsopen/zrac018
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidPellino, Gianluca [0000-0002-8322-6421]
dc.contributor.orcidFuschillo, Giacomo [0000-0002-1913-6296]
dc.contributor.orcidSimillis, Costantinos [0000-0001-8864-4350]
dc.contributor.orcidKontovounisios, Christos [0000-0002-1828-1395]
dc.identifier.eissn2474-9842
cam.issuedOnline2022-04-07


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International