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dc.contributor.authorJakubowski, Bethany Ellen
dc.contributor.authorStevens, Richard
dc.contributor.authorWilson, Hannah
dc.contributor.authorLavallee, Layla
dc.contributor.authorBrittain, Lesley
dc.contributor.authorCrawford, Carole
dc.contributor.authorHodgkinson, James
dc.contributor.authorHinton, Lisa
dc.contributor.authorMackillop, Lucy
dc.contributor.authorChappell, Lucy C
dc.contributor.authorMcManus, Richard J
dc.contributor.authorTucker, Katherine Louise
dc.date.accessioned2022-05-13T08:00:20Z
dc.date.available2022-05-13T08:00:20Z
dc.date.issued2022-12
dc.date.submitted2021-07-22
dc.identifier.issn1470-0328
dc.identifier.otherbjo17180
dc.identifier.otherbjog-21-1218.r1
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337123
dc.descriptionFunder: National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research (CLAHRC)
dc.descriptionFunder: National Institute for Health Research Oxford Biomedical Research Centre
dc.descriptionFunder: Primary Care Research Trust
dc.description.abstractOBJECTIVE: To determine the accuracy of self-testing for proteinuria during pregnancy. DESIGN: Diagnostic accuracy study. SETTING: Antenatal clinics, maternity assessment units and inpatient wards at three hospital sites. POPULATION OR SAMPLE: 345 pregnant women. METHODS: Pregnant women self-tested in-clinic for urinary protein using visually read dipsticks with samples then sent for laboratory estimation of the spot protein-creatinine ratio (PCR) (primary reference test). Secondary index tests included testing by antenatal healthcare professionals and an automated colorimetric reader. MAIN OUTCOME MEASURES: Sensitivity, specificity, negative predictive value, positive predictive value and likelihood ratios were calculated for self-testing (primary index test) along with healthcare professional and colorimetric testing compared to the primary reference test (PCR). RESULTS: 335/345 (97%) had sufficient data to be included in the analysis. Self-testing had a sensitivity of 0.71 (95% confidence interval [CI] 0.62-0.79) and a specificity of 0.89 (95% CI 0.84-0.92) compared to PCR. Sensitivity and specificity of testing by healthcare professionals and the colorimetric reader were similar: sensitivity 0.73 (95% CI 0.64-0.80) and 0.78 (95% CI 0.69-0.85), respectively; specificity 0.88 (95% CI 0.82-0.92) and 0.83 (95% CI 0.78-0.88), respectively. CONCLUSION: Pregnant women can visually read a dipstick for urinary protein with similar accuracy to antenatal healthcare professionals. Automated colorimetric testing was not significantly different, in contrast to some previous studies. Self-testing has the potential to form part of a self-monitoring regime in pregnancy.
dc.languageen
dc.publisherWiley
dc.subjectRESEARCH ARTICLE
dc.subjectRESEARCH ARTICLES
dc.subjectdiagnostic accuracy study
dc.subjecthypertension
dc.subjectpre‐eclampsia
dc.subjectpregnancy
dc.subjectproteinuria
dc.subjectself‐testing
dc.titleCross-sectional diagnostic accuracy study of self-testing for proteinuria during hypertensive pregnancies: The UDIP study.
dc.typeArticle
dc.date.updated2022-05-13T08:00:19Z
prism.publicationNameBJOG
dc.identifier.doi10.17863/CAM.84542
dcterms.dateAccepted2022-03-28
rioxxterms.versionofrecord10.1111/1471-0528.17180
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJakubowski, Bethany Ellen [0000-0003-1033-2730]
dc.identifier.eissn1471-0528
pubs.funder-project-idNational Institute for Health Research (RP‐PG‐0614‐20005)
pubs.funder-project-idNational Institute for Health Research Professorship (NIHR‐RP‐R2‐12‐015)
cam.issuedOnline2022-05-12


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