Show simple item record

dc.contributor.authorCarvalho, Luís AR
dc.contributor.authorLopes Bernardes, Goncalo
dc.date.accessioned2022-05-19T14:00:11Z
dc.date.available2022-05-19T14:00:11Z
dc.date.issued2022-07-19
dc.date.submitted2022-03-30
dc.identifier.issn1860-7179
dc.identifier.othercmdc202200174
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337303
dc.description.abstractActivity-based protein profiling (ABPP) is an approach used at the interface of chemical biology and proteomics that uses small molecular probes to provide dynamic fingerprints of enzymatic activity in complex proteomes. Malaria is a disease caused by Plasmodium parasites with a significant death burden and for which new therapies are actively being sought. Here, we compile the main achievements from ABPP studies in malaria and highlight the probes used and the different downstream platforms for data analysis. ABPP has excelled at studying Plasmodium cysteine proteases and serine hydrolase families, the targeting of the proteasome and metabolic pathways, and in the deconvolution of targets and mechanisms of known antimalarials. Despite the major impact in the field, many antimalarials and enzymatic families in Plasmodium remain to be studied, which suggests ABPP will be an evergreen technique in the field.
dc.languageen
dc.publisherWiley
dc.subjectReview
dc.subjectReviews
dc.subjectDrug Discovery
dc.subjectFluorescent probes
dc.subjectMalaria
dc.subjectMass spectrometry
dc.subjectProteomics
dc.titleThe Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.
dc.typeArticle
dc.date.updated2022-05-19T14:00:10Z
prism.publicationNameChemMedChem
dc.identifier.doi10.17863/CAM.84717
dcterms.dateAccepted2022-05-04
rioxxterms.versionofrecord10.1002/cmdc.202200174
rioxxterms.versionAO
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCarvalho, Luís AR [0000-0001-5257-7301]
dc.contributor.orcidLopes Bernardes, Goncalo [0000-0001-6594-8917]
dc.identifier.eissn1860-7187
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (101022421)
cam.issuedOnline2022-05-19


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record