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dc.contributor.authorIntroini, Viola
dc.contributor.authorMarin-Menendez, Alejandro
dc.contributor.authorNettesheim, Guilherme
dc.contributor.authorLin, Yen-Chun
dc.contributor.authorKariuki, Silvia N
dc.contributor.authorSmith, Adrian L
dc.contributor.authorJean, Letitia
dc.contributor.authorBrewin, John N
dc.contributor.authorRees, David C
dc.contributor.authorCicuta, Pietro
dc.contributor.authorRayner, Julian
dc.contributor.authorPenman, Bridget S
dc.date.accessioned2022-05-27T16:08:34Z
dc.date.available2022-05-27T16:08:34Z
dc.date.issued2022-05-27
dc.date.submitted2022-02-05
dc.identifier.issn2045-2322
dc.identifier.others41598-022-12060-4
dc.identifier.other12060
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337557
dc.descriptionFunder: EPSRC
dc.descriptionFunder: Sackler fellowship
dc.description.abstractMalaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be associated with malaria prevalence. However, the malaria protective properties of beta thalassaemic erythrocytes remain unclear. Here we studied the mechanics and surface protein expression of beta thalassaemia heterozygous erythrocytes, measured their susceptibility to P. falciparum invasion, and calculated the energy required for merozoites to invade them. We found invasion-relevant differences in beta thalassaemic cells versus matched controls, specifically: elevated membrane tension, reduced bending modulus, and higher levels of expression of the major invasion receptor basigin. However, these differences acted in opposition to each other with respect to their likely impact on invasion, and overall we did not observe beta thalassaemic cells to have lower P. falciparum invasion efficiency for any of the strains tested.
dc.languageen
dc.publisherSpringer Science and Business Media LLC
dc.subjectArticle
dc.subject/631/326/421
dc.subject/631/250/255/1629
dc.subjectarticle
dc.titleThe erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion.
dc.typeArticle
dc.date.updated2022-05-27T16:08:34Z
prism.issueIdentifier1
prism.publicationNameSci Rep
prism.volume12
dc.identifier.doi10.17863/CAM.84966
dcterms.dateAccepted2022-05-03
rioxxterms.versionofrecord10.1038/s41598-022-12060-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidIntroini, Viola [0000-0001-9012-4696]
dc.contributor.orcidMarin-Menendez, Alejandro [0000-0002-4903-6392]
dc.contributor.orcidNettesheim, Guilherme [0000-0001-7464-4333]
dc.contributor.orcidKariuki, Silvia N [0000-0003-0801-5285]
dc.contributor.orcidCicuta, Pietro [0000-0002-9193-8496]
dc.contributor.orcidRayner, Julian [0000-0002-9835-1014]
dc.contributor.orcidPenman, Bridget S [0000-0001-9803-5209]
dc.identifier.eissn2045-2322
pubs.funder-project-idWellcome Trust Junior Interdisciplinary Fellowship (Wellcome 20485/Z/16/Z)
pubs.funder-project-idWellcome Trust (206194/Z/17/Z)
cam.issuedOnline2022-05-27


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