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dc.contributor.authorSchroeder, Mariana
dc.contributor.authorBadini, Gina
dc.contributor.authorSferruzzi-Perri, Amanda N
dc.contributor.authorAlbrecht, Christiane
dc.date.accessioned2022-06-07T08:12:39Z
dc.date.available2022-06-07T08:12:39Z
dc.date.issued2022-05-20
dc.date.submitted2022-03-28
dc.identifier.issn2296-634X
dc.identifier.other906240
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337779
dc.description.abstract<jats:p>The use of assisted reproductive technologies (ART) worldwide has led to the conception and birth of over eight million babies since being implemented in 1978. ART use is currently on the rise, given growing infertility and the increase in conception age among men and women in industrialized countries. Though obstetric and perinatal outcomes have improved over the years, pregnancies achieved by ART still bear increased risks for the mother and the unborn child. Moreover, given that the first generation of ART offspring is now only reaching their forties, the long-term effects of ART are currently unknown. This is important, as there is a wealth of data showing that life-long health can be predetermined by poor conditions during intrauterine development, including irregularities in the structure and functioning of the placenta. In the current review, we aim to summarize the latest available findings examining the effects of ART on the cardiometabolic, cognitive/neurodevelopmental, and behavioral outcomes in the perinatal period, childhood and adolescence/adulthood; and to examine placental intrinsic factors that may contribute to the developmental outcomes of ART offspring. Altogether, the latest knowledge about life outcomes beyond adolescence for those conceived by ART appears to suggest a better long-term outcome than previously predicted. There are also changes in placenta structure and functional capacity with ART. However, more work in this area is critically required, since the potential consequences of ART may still emerge as the offspring gets older. In addition, knowledge of the placenta may help to foresee and mitigate any adverse outcomes in the offspring.</jats:p>
dc.languageen
dc.publisherFrontiers Media SA
dc.subjectCell and Developmental Biology
dc.subjectassisted reproductive technologies
dc.subjectplacenta
dc.subjectepigenetics
dc.subjectmetabolism
dc.subjectlong-term health
dc.subjectDOHaD
dc.subjectfetal programming
dc.titleThe Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution
dc.typeArticle
dc.date.updated2022-06-07T08:12:39Z
prism.publicationNameFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
prism.volume10
dc.identifier.doi10.17863/CAM.85188
dcterms.dateAccepted2022-05-05
rioxxterms.versionofrecord10.3389/fcell.2022.906240
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-634X
cam.issuedOnline2022-05-20


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