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dc.contributor.authorCubric-Curik, Vlatka
dc.contributor.authorNovosel, Dinko
dc.contributor.authorBrajkovic, Vladimir
dc.contributor.authorRota Stabelli, Omar
dc.contributor.authorKrebs, Stefan
dc.contributor.authorSölkner, Johann
dc.contributor.authorŠalamon, Dragica
dc.contributor.authorRistov, Strahil
dc.contributor.authorBerger, Beate
dc.contributor.authorTrivizaki, Stamatina
dc.contributor.authorBizelis, Iosif
dc.contributor.authorFerenčaković, Maja
dc.contributor.authorRothammer, Sophie
dc.contributor.authorKunz, Elisabeth
dc.contributor.authorSimčič, Mojca
dc.contributor.authorDovč, Peter
dc.contributor.authorBunevski, Gojko
dc.contributor.authorBytyqi, Hysen
dc.contributor.authorMarković, Božidarka
dc.contributor.authorBrka, Muhamed
dc.contributor.authorKume, Kristaq
dc.contributor.authorStojanović, Srđan
dc.contributor.authorNikolov, Vasil
dc.contributor.authorZinovieva, Natalia
dc.contributor.authorSchönherz, Anna Amanda
dc.contributor.authorGuldbrandtsen, Bernt
dc.contributor.authorČačić, Mato
dc.contributor.authorRadović, Siniša
dc.contributor.authorMiracle, Preston
dc.contributor.authorVernesi, Cristiano
dc.contributor.authorCurik, Ino
dc.contributor.authorMedugorac, Ivica
dc.date.accessioned2022-06-07T08:15:51Z
dc.date.available2022-06-07T08:15:51Z
dc.date.issued2021-11-27
dc.identifier.issn1752-4571
dc.identifier.other35505892
dc.identifier.otherPMC9046920
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337815
dc.description.abstractThe contribution of domestic cattle in human societies is enormous, making cattle, along with other essential benefits, the economically most important domestic animal in the world today. To expand existing knowledge on cattle domestication and mitogenome diversity, we performed a comprehensive complete mitogenome analysis of the species (802 sequences, 114 breeds). A large sample was collected in South-east Europe, an important agricultural gateway to Europe during Neolithization and a region rich in cattle biodiversity. We found 1725 polymorphic sites (810 singletons, 853 parsimony-informative sites and 57 indels), 701 unique haplotypes, a haplotype diversity of 0.9995 and a nucleotide diversity of 0.0015. In addition to the dominant T<sub>3</sub> and several rare haplogroups (Q, T<sub>5</sub>, T<sub>4</sub>, T<sub>2</sub> and T<sub>1</sub>), we have identified maternal line in Austrian Murbodner cattle that possess surviving aurochs' mitochondria haplotype P<sub>1</sub> that diverged prior to the Neolithization process. This is convincing evidence for rare female-mediated adaptive introgression of wild aurochs into domesticated cattle in Europe. We revalidated the existing haplogroup classification and provided Bayesian phylogenetic inference with a more precise estimated divergence time than previously available. Occasionally, classification based on partial mitogenomes was not reliable; for example, some individuals with haplogroups P and T<sub>5</sub> were not recognized based on D-loop information. Bayesian skyline plot estimates (median) show that the earliest population growth began before domestication in cattle with haplogroup T<sub>2</sub>, followed by Q (~10.0-9.5 kyBP), whereas cattle with T<sub>3</sub> (~7.5 kyBP) and T<sub>1</sub> (~3.0-2.5 kyBP) expanded later. Overall, our results support the existence of interactions between aurochs and cattle during domestication and dispersal of cattle in the past, contribute to the conservation of maternal cattle diversity and enable functional analyses of the surviving aurochs P<sub>1</sub> mitogenome.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101461828
dc.sourceessn: 1752-4571
dc.subjectDiversity
dc.subjectCattle
dc.subjectDomestication
dc.subjectphylogenetics
dc.subjectMitogenome
dc.subjectAurochs Introgression
dc.titleLarge-scale mitogenome sequencing reveals consecutive expansions of domestic taurine cattle and supports sporadic aurochs introgression.
dc.typeArticle
dc.date.updated2022-06-07T08:15:50Z
prism.endingPage678
prism.issueIdentifier4
prism.publicationNameEvolutionary applications
prism.startingPage663
prism.volume15
dc.identifier.doi10.17863/CAM.85224
rioxxterms.versionofrecord10.1111/eva.13315
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidCubric-Curik, Vlatka [0000-0002-2223-5957]
dc.contributor.orcidSölkner, Johann [0000-0002-1517-5829]


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International