Show simple item record

dc.contributor.authorMcDonald, Stephen
dc.contributor.authorYiu, Sean
dc.contributor.authorSu, Li
dc.contributor.authorGordon, Caroline
dc.contributor.authorTruman, Matt
dc.contributor.authorLisk, Laura
dc.contributor.authorSolomons, Neil
dc.contributor.authorBruce, Ian N
dc.contributor.authorMASTERPLANS Consortium
dc.date.accessioned2022-06-07T08:17:30Z
dc.date.available2022-06-07T08:17:30Z
dc.date.issued2022-05
dc.date.submitted2021-09-15
dc.identifier.issn2053-8790
dc.identifier.otherlupus-2021-000584
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337855
dc.description.abstractOBJECTIVES: To identify predictors of overall lupus and lupus nephritis (LN) responses in patients with LN. METHODS: Data from the Aspreva Lupus Management Study (ALMS) trial cohort was used to identify baseline predictors of response at 6 months. Endpoints were major clinical response (MCR), improvement, complete renal response (CRR) and partial renal response (PRR). Univariate and multivariate logistic regressions with least absolute shrinkage and selection operator (LASSO) and cross-validation in randomly split samples were utilised. Predictors were ranked by the percentage of times selected by LASSO and prediction performance was assessed by the area under the receiver operating characteristics (AUROC) curve. RESULTS: We studied 370 patients in the ALMS induction trial. Improvement at 6 months was associated with older age (OR=1.03 (95% CI: 1.01 to 1.05) per year), normal haemoglobin (1.85 (1.16 to 2.95) vs low haemoglobin), active lupus (British Isles Lupus Assessment Group A or B) in haematological and mucocutaneous domains (0.61 (0.39 to 0.97) and 0.50 (0.31 to 0.81)), baseline damage (SDI>1 vs =0) (0.38 (0.16 to 0.91)) and 24-hour urine protein (0.63 (0.50 to 0.80)). LN duration 2-4 years (0.43 (0.19 to 0.97) vs <1 year) and 24-hour urine protein (0.63 (0.45 to 0.89)) were negative predictors of CRR. LN duration 2-4 years (0.45 (0.24 to 0.83) vs <1 year) negatively predicted PRR. The AUROCs of models for improvement, CRR and PRR were 0.56, 0.55 and 0.51 respectively. CONCLUSIONS: Baseline variables predicted 6-month outcomes in patients with SLE. While the modest performance of models emphasises the need for new biomarkers to advance this field, the factors identified can help identify those patients who may require novel treatment strategies.
dc.languageen
dc.publisherBMJ
dc.subjectBiomarker studies
dc.subject1506
dc.subject2253
dc.subjectcyclophosphamide
dc.subjecttreatment
dc.subjectlupus nephritis
dc.titlePredictors of treatment response in a lupus nephritis population: lessons from the Aspreva Lupus Management Study (ALMS) trial.
dc.typeArticle
dc.date.updated2022-06-07T08:17:30Z
prism.issueIdentifier1
prism.publicationNameLupus Sci Med
prism.volume9
dc.identifier.doi10.17863/CAM.85264
dcterms.dateAccepted2022-02-09
rioxxterms.versionofrecord10.1136/lupus-2021-000584
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.licenseref.startdate2022-05-30
dc.contributor.orcidMcDonald, Stephen [0000-0001-7151-7654]
dc.contributor.orcidSu, Li [0000-0003-0919-3462]
dc.contributor.orcidBruce, Ian N [0000-0003-3047-500X]
dc.identifier.eissn2053-8790
cam.issuedOnline2022-05-31
rioxxterms.freetoread.startdate2022-05-30
rioxxterms.freetoread.startdate2022-05-30


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record