Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.
Cox, Sylvia ML
Scala, Stephanie G
DuBois, Jonathan M
Koepp, Matthias J
Duncan, John S
Fryer, Tim D
Aigbirhio, Franklin I
McGinnity, Colm J
Springer Science and Business Media LLC
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Hansen, J. Y., Shafiei, G., Markello, R. D., Smart, K., Cox, S. M., Nørgaard, M., Beliveau, V., et al. (2022). Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.. Nat Neurosci https://doi.org/10.1038/s41593-022-01186-3
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.
For the Cambridge authors (Coles, Fryer & Aigbirhio): This work was funded by an MRC PET Neuroscience programme grant (Training and Novel Probes Programme in PET Neurochemistry - MR/K02308X/1) and by an MRC Developmental Pathway Funding Scheme grant (MR/L013215/1). This research in Cambridge was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. JPC was supported by a British Journal of Anaesthesia/Royal College of Anaesthetists grant from the National Institute of Academic Anaesthesia.
Medical Research Council (MR/K02308X/1)
Medical Research Council (MR/L013215/1)
National Institute for Health Research (IS-BRC-1215-20014)
External DOI: https://doi.org/10.1038/s41593-022-01186-3
This record's URL: https://www.repository.cam.ac.uk/handle/1810/338012
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