Show simple item record

dc.contributor.authorIntroini, Viola
dc.contributor.authorGovendir, Matt A
dc.contributor.authorRayner, Julian
dc.contributor.authorCicuta, Pietro
dc.contributor.authorBernabeu, Maria
dc.date.accessioned2022-06-14T08:00:23Z
dc.date.available2022-06-14T08:00:23Z
dc.date.issued2022
dc.date.submitted2022-03-30
dc.identifier.issn2235-2988
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338068
dc.description.abstractForces and mechanical properties of cells and tissues set constraints on biological functions, and are key determinants of human physiology. Changes in cell mechanics may arise from disease, or directly contribute to pathogenesis. Malaria gives many striking examples. Plasmodium parasites, the causative agents of malaria, are single-celled organisms that cannot survive outside their hosts; thus, thost-pathogen interactions are fundamental for parasite's biological success and to the host response to infection. These interactions are often combinations of biochemical and mechanical factors, but most research focuses on the molecular side. However, Plasmodium infection of human red blood cells leads to changes in their mechanical properties, which has a crucial impact on disease pathogenesis because of the interaction of infected red blood cells with other human tissues through various adhesion mechanisms, which can be probed and modelled with biophysical techniques. Recently, natural polymorphisms affecting red blood cell biomechanics have also been shown to protect human populations, highlighting the potential of understanding biomechanical factors to inform future vaccines and drug development. Here we review biophysical techniques that have revealed new aspects of Plasmodium falciparum invasion of red blood cells and cytoadhesion of infected cells to the host vasculature. These mechanisms occur differently across Plasmodium species and are linked to malaria pathogenesis. We highlight promising techniques from the fields of bioengineering, immunomechanics, and soft matter physics that could be beneficial for studying malaria. Some approaches might also be applied to other phases of the malaria lifecycle and to apicomplexan infections with complex host-pathogen interactions.
dc.languageen
dc.publisherFrontiers Media SA
dc.subjectCellular and Infection Microbiology
dc.subjectmalaria
dc.subjectbiophysics
dc.subjectimaging
dc.subjectPlasmodium
dc.subjectcytoadhesion
dc.subjectmicrofluidics
dc.subjectmechanobiology
dc.titleBiophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.
dc.typeArticle
dc.date.updated2022-06-14T08:00:22Z
prism.publicationNameFront Cell Infect Microbiol
prism.volume12
dc.identifier.doi10.17863/CAM.85477
dcterms.dateAccepted2022-04-27
rioxxterms.versionofrecord10.3389/fcimb.2022.908241
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidRayner, Julian [0000-0002-9835-1014]
dc.identifier.eissn2235-2988
pubs.funder-project-idEngineering and Physical Sciences Research Council (EP/R011443/1)
cam.issuedOnline2022-05-31


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record