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dc.contributor.authorJahangiri, Leila
dc.contributor.authorIshola, Tala
dc.date.accessioned2022-06-15T01:05:12Z
dc.date.available2022-06-15T01:05:12Z
dc.date.issued2022-05-09
dc.identifier.issn1422-0067
dc.identifier.other35563661
dc.identifier.otherPMC9105119
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338104
dc.description.abstractBreast cancer (BC) is the most frequently diagnosed cancer in women for which numerous diagnostic and therapeutic options have been developed. Namely, the targeted treatment of BC, for the most part, relies on the expression of growth factors and hormone receptors by these cancer cells. Despite this, close to 30% of BC patients may experience relapse due to the presence of minimal residual disease (MRD) consisting of surviving disseminated tumour cells (DTCs) from the primary tumour which can colonise a secondary site. This can lead to either detectable metastasis or DTCs entering a dormant state for a prolonged period where they are undetectable. In the latter, cells can re-emerge from their dormant state due to intrinsic and microenvironmental cues leading to relapse and metastatic outgrowth. Pre- and clinical studies propose that targeting dormant DTCs may inhibit metastasis, but the choice between keeping them dormant or forcing their "awakening" is still controversial. This review will focus on cancer cells' microenvironmental cues and metabolic and molecular properties, which lead to dormancy, relapse, and metastatic latency in BC. Furthermore, we will focus on the role of autophagy, long non-coding RNAs (lncRNAs), miRNAs, and exosomes in influencing the induction of dormancy and awakening of dormant BC cells. In addition, we have analysed BC treatment from a viewpoint of autophagy, lncRNAs, miRNAs, and exosomes. We propose the targeted modulation of these processes and molecules as modern aspects of precision medicine for BC treatment, improving both novel and traditional BC treatment options. Understanding these pathways and processes may ultimately improve BC patient prognosis, patient survival, and treatment response.
dc.languageeng
dc.publisherMDPI AG
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101092791
dc.sourceessn: 1422-0067
dc.subjectDormancy
dc.subjectBreast cancer
dc.subjectTreatment
dc.subjectmiRNAs
dc.subjectAutophagy
dc.subjectExosomes
dc.subjectLncrnas
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectNeoplasm Recurrence, Local
dc.subjectMicroRNAs
dc.subjectFemale
dc.subjectRNA, Long Noncoding
dc.titleDormancy in Breast Cancer, the Role of Autophagy, lncRNAs, miRNAs and Exosomes.
dc.typeArticle
dc.date.updated2022-06-15T01:05:11Z
prism.issueIdentifier9
prism.publicationNameInt J Mol Sci
prism.volume23
dc.identifier.doi10.17863/CAM.85513
dcterms.dateAccepted2022-05-06
rioxxterms.versionofrecord10.3390/ijms23095271
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidJahangiri, Leila [0000-0003-0235-8447]
dc.identifier.eissn1422-0067
cam.issuedOnline2022-05-09


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International