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dc.contributor.authorRooney, James
dc.contributor.authorNorthcote, Holly M
dc.contributor.authorWilliams, Tim L
dc.contributor.authorCortés, Alba
dc.contributor.authorCantacessi, Cinzia
dc.contributor.authorMorphew, Russell M
dc.date.accessioned2022-06-16T23:30:10Z
dc.date.available2022-06-16T23:30:10Z
dc.date.issued2022-09
dc.identifier.issn1471-4922
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338169
dc.description.abstractInfections by gastrointestinal (GI) helminths have been associated with significant alterations of the structure of microbial communities inhabiting the host gut. However, current understanding of the biological mechanisms that regulate these relationships is still lacking. We propose that helminth-derived extracellular vesicles (EVs) likely represent key players in helminth-microbiota crosstalk. Here, we explore knowledge of helminth EVs with an emphasis on their putative antimicrobial properties, and we argue that (i) an enhanced understanding of the mechanisms governing such interactions might assist the discovery and development of novel strategies of parasite control, and that (ii) the identification and characterisation of helminth molecules with antimicrobial properties might pave the way towards the discovery of novel antibiotics, thus aiding the global fight against antimicrobial resistance.
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleParasitic helminths and the host microbiome - a missing 'extracellular vesicle-sized' link?
dc.typeArticle
dc.publisher.departmentDepartment of Veterinary Medicine
dc.date.updated2022-06-15T17:48:59Z
prism.publicationNameTrends Parasitol
dc.identifier.doi10.17863/CAM.85580
dcterms.dateAccepted2022-06-15
rioxxterms.versionofrecord10.1016/j.pt.2022.06.003
rioxxterms.versionAM
dc.contributor.orcidWilliams, Timothy [0000-0002-9775-8285]
dc.contributor.orcidCantacessi, Cinzia [0000-0001-6863-2950]
dc.identifier.eissn1471-5007
rioxxterms.typeJournal Article/Review
cam.issuedOnline2022-07-09
cam.orpheus.successWed Aug 03 09:45:52 BST 2022 - Embargo updated
cam.orpheus.counter4
cam.depositDate2022-06-15
pubs.licence-identifierapollo-deposit-licence-2-1
pubs.licence-display-nameApollo Repository Deposit Licence Agreement
rioxxterms.freetoread.startdate2023-07-09


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International