Show simple item record

dc.contributor.authorIntroini, Viola
dc.contributor.authorMarin-Menendez, Alejandro
dc.contributor.authorNettesheim, Guilherme
dc.contributor.authorLin, Yen-Chun
dc.contributor.authorKariuki, Silvia N
dc.contributor.authorSmith, Adrian L
dc.contributor.authorJean, Letitia
dc.contributor.authorBrewin, John N
dc.contributor.authorRees, David C
dc.contributor.authorCicuta, Pietro
dc.contributor.authorRayner, Julian C
dc.contributor.authorPenman, Bridget S
dc.date.accessioned2022-06-29T19:48:58Z
dc.date.available2022-06-29T19:48:58Z
dc.date.issued2022-05-27
dc.identifier.issn2045-2322
dc.identifier.other35624125
dc.identifier.otherPMC9142571
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338576
dc.description.abstractMalaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be associated with malaria prevalence. However, the malaria protective properties of beta thalassaemic erythrocytes remain unclear. Here we studied the mechanics and surface protein expression of beta thalassaemia heterozygous erythrocytes, measured their susceptibility to P. falciparum invasion, and calculated the energy required for merozoites to invade them. We found invasion-relevant differences in beta thalassaemic cells versus matched controls, specifically: elevated membrane tension, reduced bending modulus, and higher levels of expression of the major invasion receptor basigin. However, these differences acted in opposition to each other with respect to their likely impact on invasion, and overall we did not observe beta thalassaemic cells to have lower P. falciparum invasion efficiency for any of the strains tested.
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2045-2322
dc.sourcenlmid: 101563288
dc.subjectErythrocyte Membrane
dc.subjectHumans
dc.subjectPlasmodium falciparum
dc.subjectMalaria
dc.subjectMalaria, Falciparum
dc.subjectbeta-Thalassemia
dc.subjectHeterozygote
dc.titleThe erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion.
dc.typeArticle
dc.date.updated2022-06-29T19:48:58Z
prism.issueIdentifier1
prism.publicationNameSci Rep
prism.volume12
dc.identifier.doi10.17863/CAM.85989
dcterms.dateAccepted2022-05-03
rioxxterms.versionofrecord10.1038/s41598-022-12060-4
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidIntroini, Viola [0000-0001-9012-4696]
dc.contributor.orcidMarin-Menendez, Alejandro [0000-0002-4903-6392]
dc.contributor.orcidNettesheim, Guilherme [0000-0001-7464-4333]
dc.contributor.orcidKariuki, Silvia N [0000-0003-0801-5285]
dc.contributor.orcidCicuta, Pietro [0000-0002-9193-8496]
dc.contributor.orcidRayner, Julian C [0000-0002-9835-1014]
dc.contributor.orcidPenman, Bridget S [0000-0001-9803-5209]
dc.identifier.eissn2045-2322
pubs.funder-project-idWellcome Trust Junior Interdisciplinary Fellowship (Wellcome 20485/Z/16/Z)
pubs.funder-project-idWellcome Trust (20485/Z/16/Z, 220266/Z/20/Z, 206194/Z/17/Z)
cam.issuedOnline2022-05-27


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International