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The University of Cambridge School of Clinical Medicine aims to provide leadership in education, discovery and healthcare. The School will achieve this through: inspirational teaching and training, outstanding basic and clinical research and integration of these to improve medical practice for both individual patients and the population.

Find out more about the School of Clinical Medicine at http://www.medschl.cam.ac.uk/.

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  • Development of an Optogenetic Toolkit for the Interrogation of T cell Signalling Dynamics 

    Harris, Michael James (2018-04-20)
    T cells are a cornerstone of the mammalian adaptive immune system. A range of T-cell subsets exist that can orchestrate the overall immune response to pathogens or cancers, either by directly killing infected cells or ...
  • Mutational Spectrum in a Worldwide Study of 29,700 Families with BRCA1 or BRCA2 Mutations. 

    Rebbeck, Timothy R; Friebel, Tara M; Friedman, Eitan; Hamann, Ute; Huo, Dezheng; Kwong, Ava; Olah, Edith et al. (Wiley-Blackwell, 2018-02-15)
    The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on Caucasians in Europe and North America. The Consortium of Investigators ...
  • GDF15 and metabolism: homing in on a new therapy 

    Yeo, Giles See; Anthony P, Coll; Irene, Cimino
    Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15, increasing the mechanistic understanding of its effect and paving the way for the development of novel ...
  • Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci. 

    Jubb, Alasdair William; Boyle, Shelagh; Hume, David A; Bickmore, Wendy A (2017-12-12)
    Glucocorticoids act by binding to the glucocorticoid receptor (GR), which binds to specific motifs within enhancers of target genes to activate transcription. Previous studies have suggested that GRs can promote interactions ...

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