Predicted structural models of alphaherpesvirus pUL21 homologues in complex with human protein phosphatase one (PP1)
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Theoretical models of herpes simplex virus (HSV)-1 protein pUL21 and varicella-zoster virus (VZV) pORF38 in complex with the catalytic domain of human PP1[gamma]. Models were generated using AlphaFold2 via the ColabFold pipeline with input sequences of pUL21 from HSV-1 strain KOS (UniProt F8RG07 residues 1-535) or pORF38 from VZV strain Dumas (UniProt P09289 residues 1-541) plus human PP1 gamma catalytic domain (UniProt P36873 residues 7-300).
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Compressed (zip) files can be extracted using inbuilt operating system tools or 7-zip (https://www.7-zip.org/). Coordinate files (.pdb) can be opened with PyMOL (https://github.com/schrodinger/pymol-open-source) or ChimeraX (https://www.rbvi.ucsf.edu/chimerax/). json files can be opened using text editors or parsed using Python (https://docs.python.org/3/library/json.html). Sequence alignment (.a3m), log (.log), comma-separated value (.csv) and text (.txt) files can be opened using text editors. Images (.png) and documents (.pdf) can be opened using operating system tools.
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Except where otherwised noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)
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British Skin Foundation (028/S/22)
Wellcome Trust (098406/Z/12/B)
Wellcome Trust (098406/Z/12/B)