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Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves

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dc.contributor.authorGupta, Isha
dc.contributor.authorCassará, Antonino M.
dc.contributor.authorTarotin, Ilya
dc.contributor.authorDonega, Matteo
dc.contributor.authorMiranda, Jason A.
dc.contributor.authorSokal, David M.
dc.contributor.authorOuchouche, Sebastien
dc.contributor.authorDopson, Wesley
dc.contributor.authorMatteucci, Paul
dc.contributor.authorNeufeld, Esra
dc.contributor.authorSchiefer, Matthew A.
dc.contributor.authorRowles, Alison
dc.contributor.authorMcGill, Paul
dc.contributor.authorPerkins, Justin
dc.contributor.authorDolezalova, Nikola
dc.contributor.authorSaeb-Parsy, Kourosh
dc.contributor.authorKuster, Niels
dc.contributor.authorYazicioglu, Refet Firat
dc.contributor.authorWitherington, Jason
dc.contributor.authorChew, Daniel J.
dc.contributor.orcidGupta, Isha [0000-0003-3766-0857]
dc.contributor.orcidCassará, Antonino M. [0000-0003-3375-7440]
dc.contributor.orcidMiranda, Jason A. [0000-0002-1459-2022]
dc.contributor.orcidSokal, David M. [0000-0003-3150-7990]
dc.contributor.orcidNeufeld, Esra [0000-0001-5528-6147]
dc.contributor.orcidDolezalova, Nikola [0000-0002-9665-1275]
dc.contributor.orcidSaeb-Parsy, Kourosh [0000-0002-0633-3696]
dc.contributor.orcidChew, Daniel J. [0000-0002-4937-4797]
dc.date.accessioned2021-10-18T08:48:45Z
dc.date.available2021-10-18T08:48:45Z
dc.date.issued2020-10-16
dc.date.submitted2020-02-04
dc.date.updated2021-10-18T08:48:44Z
dc.description.abstractAbstract: Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, autonomic nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these nerves contain axons with populations of varying phenotypes leading to complexities for axon engagement and activation. Thirdly, clinical translational of methodologies attained using preclinical animal models are limited due to heterogeneity of the intra- and inter-species comparative anatomy and physiology. Here we demonstrate how this can be accomplished by the use of in silico modelling of target anatomy, and validation of these estimations through ex vivo human tissue electrophysiology studies. Neuroelectrical models are developed to address the challenges in translation of parameters, which provides strong input criteria for device design and dose selection prior to a first-in-human trial.
dc.identifier.doi10.17863/CAM.76984
dc.identifier.eissn2399-3642
dc.identifier.others42003-020-01299-0
dc.identifier.other1299
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/329536
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/1647/1453
dc.subject/692/308/575
dc.subject/631/114/2397
dc.subject/14/28
dc.subject/9/30
dc.subjectarticle
dc.titleQuantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves
dc.typeArticle
dcterms.dateAccepted2020-09-15
prism.issueIdentifier1
prism.publicationNameCommunications Biology
prism.volume3
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s42003-020-01299-0

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