Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines


Type
Article
Change log
Authors
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Bosica, F 
Rowe, SM 
Lacerda Abreu, B 
Godineau, E 
Abstract

We report the multistep continuous process for the preparation of dibromoformaldoxime (DBFO) as a precursor to generate 3-bromoisoxazolines. We also report process improvements that afford a productivity of over 620 mmol h−1 of DBFO.

Description
Keywords
3405 Organic Chemistry, 34 Chemical Sciences
Journal Title
Organic Process Research and Development
Conference Name
Journal ISSN
1083-6160
1520-586X
Volume Title
Publisher
American Chemical Society
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/M004120/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
We would like to thank Syngenta Crop Protection AG (CB) and the EPSRC (SVL, grant nos. EP/K009494/1, EP/ M004120/1, and EP/K039520/1) for financial support.
Relationships
Is supplemented by: