Cognitive decline and quality of life in incident Parkinson's disease: The role of attention.


Type
Article
Change log
Authors
Lawson, Rachael A 
Yarnall, Alison J 
Duncan, Gordon W 
Breen, David P 
Khoo, Tien K 
Abstract

INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort. METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition. RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01). CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.

Description
Keywords
Attention, Dementia, Mild cognitive impairment, Parkinson's disease, Quality of life, Aged, Aged, 80 and over, Attention, Cognitive Dysfunction, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease, Quality of Life
Journal Title
Parkinsonism Relat Disord
Conference Name
Journal ISSN
1353-8020
1873-5126
Volume Title
27
Publisher
Elsevier BV
Sponsorship
Parkinson's UK (via Newcastle University) (RES/0211/7258)
Parkinson's UK (via Newcastle University) (RES/0168/7579)
Wellcome Trust (103838/Z/14/Z)
Medical Research Council (MC_U105597119)