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Models and Tools for Studying Enteroendocrine Cells.

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cam.issuedOnline2018-09-14
dc.contributor.authorGoldspink, Deborah A
dc.contributor.authorReimann, Frank
dc.contributor.authorGribble, Fiona M
dc.contributor.orcidReimann, Frank [0000-0001-9399-6377]
dc.contributor.orcidGribble, Fiona [0000-0002-4232-2898]
dc.date.accessioned2018-12-13T00:32:55Z
dc.date.available2018-12-13T00:32:55Z
dc.date.issued2018-12-01
dc.description.abstractGut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes. Understanding the function of enteroendocrine cells and the molecular mechanisms driving hormone production is a key step toward mobilizing endogenous hormone reserves in the gut as a therapeutic strategy. In this review, we will discuss the variety of ex vivo and in vitro model systems driving this research and their contributions to our current understanding of nutrient-sensing mechanisms in enteroendocrine cells.
dc.format.mediumPrint
dc.identifier.doi10.17863/CAM.34160
dc.identifier.eissn1945-7170
dc.identifier.issn0013-7227
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/286854
dc.languageeng
dc.language.isoeng
dc.publisherThe Endocrine Society
dc.publisher.urlhttp://dx.doi.org/10.1210/en.2018-00672
dc.subjectAnimals
dc.subjectEating
dc.subjectEndocrinology
dc.subjectEnteroendocrine Cells
dc.subjectGastrointestinal Hormones
dc.subjectGastrointestinal Tract
dc.subjectHomeostasis
dc.subjectHumans
dc.subjectModels, Biological
dc.titleModels and Tools for Studying Enteroendocrine Cells.
dc.typeArticle
dcterms.dateAccepted2018-09-05
prism.endingPage3884
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameEndocrinology
prism.startingPage3874
prism.volume159
pubs.funder-project-idMedical Research Council (MC_UU_12012/3)
pubs.funder-project-idWellcome Trust (106262/Z/14/Z)
pubs.funder-project-idMedical Research Council (MC_UU_12012/5)
pubs.funder-project-idMRC (MC_UU_00014/3)
pubs.funder-project-idMRC (MC_UU_00014/5)
pubs.funder-project-idMedical Research Council (MC_PC_12012)
rioxxterms.licenseref.startdate2018-12
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1210/en.2018-00672

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