Ratcheted diffusion transport through crowded nanochannels.
| cam.issuedOnline | 2013-10-31 | |
| dc.contributor.author | Lappala, Anna | |
| dc.contributor.author | Zaccone, Alessio | |
| dc.contributor.author | Terentjev, Eugene M | |
| dc.contributor.orcid | Terentjev, Eugene [0000-0003-3517-6578] | |
| dc.date.accessioned | 2021-10-26T23:30:40Z | |
| dc.date.available | 2021-10-26T23:30:40Z | |
| dc.date.issued | 2013-10-31 | |
| dc.description.abstract | The problem of transport through nanochannels is one of the major questions in cell biology, with a wide range of applications. In this paper we discuss the process of spontaneous translocation of molecules (Brownian particles) by ratcheted diffusion: a problem relevant for protein translocation along bacterial flagella or injectosome complex, or DNA translocation by bacteriophages. We use molecular dynamics simulations and statistical theory to identify two regimes of transport: at low rate of particle injection into the channel the process is controlled by the individual diffusion towards the open end (the first passage problem), while at a higher rate of injection the crowded regime sets in. In this regime the particle density in the channel reaches a constant saturation level and the resistance force increases substantially, due to the osmotic pressure build-up. To achieve a steady-state transport, the apparatus that injects new particles into a crowded channel has to operate with an increasing power consumption, proportional to the length of the channel and the required rate of transport. The analysis of resistance force, and accordingly--the power required to inject the particles into a crowded channel to overcome its clogging, is also relevant for many microfluidics applications. | |
| dc.format.medium | Electronic | |
| dc.identifier.doi | 10.17863/CAM.77366 | |
| dc.identifier.eissn | 2045-2322 | |
| dc.identifier.issn | 2045-2322 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/329923 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.publisher.url | http://dx.doi.org/10.1038/srep03103 | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | cond-mat.soft | |
| dc.subject | cond-mat.soft | |
| dc.title | Ratcheted diffusion transport through crowded nanochannels. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2013-10-16 | |
| prism.publicationDate | 2013 | |
| prism.publicationName | Sci Rep | |
| prism.startingPage | 3103 | |
| prism.volume | 3 | |
| pubs.funder-project-id | Engineering and Physical Sciences Research Council (EP/F032773/1) | |
| rioxxterms.licenseref.startdate | 2013-10-31 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | VoR | |
| rioxxterms.versionofrecord | 10.1038/srep03103 |
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