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The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches.

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cam.issuedOnline2018-09-06
dc.contributor.authorGruel, Jérémy
dc.contributor.authorDeichmann, Julia
dc.contributor.authorLandrein, Benoit
dc.contributor.authorHitchcock, Thomas
dc.contributor.authorJönsson, Henrik
dc.contributor.orcidLandrein, Benoit [0000-0002-2371-9996]
dc.contributor.orcidJonsson, Henrik [0000-0003-2340-588X]
dc.date.accessioned2018-11-16T00:31:16Z
dc.date.available2018-11-16T00:31:16Z
dc.date.issued2018
dc.description.abstractThe plant shoot apical meristem holds a stem cell niche from which all aerial organs originate. Using a computational approach we show that a mixture of monomers and heterodimers of the transcription factors WUSCHEL and HAIRY MERISTEM is sufficient to pattern the stem cell niche, and predict that immobile heterodimers form a regulatory "pocket" surrounding the stem cells. The model achieves to reproduce an array of perturbations, including mutants and tissue size modifications. We also show its ability to reproduce the recently observed dynamical shift of the stem cell niche during the development of an axillary meristem. The work integrates recent experimental results to answer the longstanding question of how the asymmetry of expression between the stem cell marker CLAVATA3 and its activator WUSCHEL is achieved, and recent findings of plasticity in the system.
dc.description.sponsorshipGatsby Charitable Foundation (GAT3395-PR4)
dc.format.mediumElectronic-eCollection
dc.identifier.doi10.17863/CAM.32519
dc.identifier.eissn2056-7189
dc.identifier.issn2056-7189
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/285149
dc.languageeng
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.publisher.urlhttp://dx.doi.org/10.1038/s41540-018-0072-1
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject0601 Biochemistry and Cell Biology
dc.subject0604 Genetics
dc.subjectBasic Science
dc.subjectStem Cell Research - Nonembryonic - Non-Human
dc.subjectRegenerative Medicine
dc.subjectStem Cell Research
dc.subjectGeneric Health Relevance
dc.subject1.1 Normal biological development and functioning
dc.titleThe interaction of transcription factors controls the spatial layout of plant aerial stem cell niches.
dc.typeArticle
dcterms.dateAccepted2018-07-31
prism.publicationDate2018
prism.publicationNameNPJ Syst Biol Appl
prism.startingPage36
prism.volume4
pubs.funder-project-idGatsby Charitable Foundation (unknown)
pubs.funder-project-idGatsby Charitable Foundation (GAT3395/PR4)
rioxxterms.licenseref.startdate2018-01
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s41540-018-0072-1

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