Repository logo
 

Circadian Entrainment in Arabidopsis by the Sugar-Responsive Transcription Factor bZIP63.

Simple item page
cam.issuedOnline2018-08-02
dc.contributor.authorFrank, Alexander
dc.contributor.authorMatiolli, Cleverson C
dc.contributor.authorViana, Américo JC
dc.contributor.authorHearn, Timothy J
dc.contributor.authorKusakina, Jelena
dc.contributor.authorBelbin, Fiona E
dc.contributor.authorWells Newman, David
dc.contributor.authorYochikawa, Aline
dc.contributor.authorCano-Ramirez, Dora L
dc.contributor.authorChembath, Anupama
dc.contributor.authorCragg-Barber, Kester
dc.contributor.authorHaydon, Michael J
dc.contributor.authorHotta, Carlos T
dc.contributor.authorVincentz, Michel
dc.contributor.authorWebb, Alex AR
dc.contributor.authorDodd, Antony N
dc.contributor.orcidHearn, Timothy [0000-0001-6827-4196]
dc.contributor.orcidCano Ramirez, Dora [0000-0002-5713-8284]
dc.contributor.orcidWebb, Alex [0000-0003-0261-4375]
dc.date.accessioned2018-09-20T12:03:28Z
dc.date.available2018-09-20T12:03:28Z
dc.date.issued2018-08-20
dc.description.abstractSynchronization of circadian clocks to the day-night cycle ensures the correct timing of biological events. This entrainment process is essential to ensure that the phase of the circadian oscillator is synchronized with daily events within the environment [1], to permit accurate anticipation of environmental changes [2, 3]. Entrainment in plants requires phase changes in the circadian oscillator, through unidentified pathways, which alter circadian oscillator gene expression in response to light, temperature, and sugars [4-6]. To determine how circadian clocks respond to metabolic rhythms, we investigated the mechanisms by which sugars adjust the circadian phase in Arabidopsis [5]. We focused upon metabolic regulation because interactions occur between circadian oscillators and metabolism in several experimental systems [5, 7-9], but the molecular mechanisms are unidentified. Here, we demonstrate that the transcription factor BASIC LEUCINE ZIPPER63 (bZIP63) regulates the circadian oscillator gene PSEUDO RESPONSE REGULATOR7 (PRR7) to change the circadian phase in response to sugars. We find that SnRK1, a sugar-sensing kinase that regulates bZIP63 activity and circadian period [10-14] is required for sucrose-induced changes in circadian phase. Furthermore, TREHALOSE-6-PHOSPHATE SYNTHASE1 (TPS1), which synthesizes the signaling sugar trehalose-6-phosphate, is required for circadian phase adjustment in response to sucrose. We demonstrate that daily rhythms of energy availability can entrain the circadian oscillator through the function of bZIP63, TPS1, and the KIN10 subunit of the SnRK1 energy sensor. This identifies a molecular mechanism that adjusts the circadian phase in response to sugars.
dc.description.sponsorshipFAPESP, The Royal Society, the Bristol Centre for Agricultural Innovation, the Peter und Traudl Engelhorn-Stiftung, the National Council of Technological and Scientific Development (CNPq) (Brazil), and Consejo Nacional de Ciencia y Tecnología (Mexico)
dc.format.mediumPrint-Electronic
dc.identifier.doi10.17863/CAM.27814
dc.identifier.eissn1879-0445
dc.identifier.issn0960-9822
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/280443
dc.languageeng
dc.language.isoeng
dc.publisherElsevier BV
dc.publisher.urlhttp://dx.doi.org/10.1016/j.cub.2018.05.092
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcircadian rhythms
dc.subjectmetabolism
dc.subjectsignal transduction
dc.subjectsugar signaling
dc.subjectArabidopsis
dc.subjectArabidopsis Proteins
dc.subjectBasic-Leucine Zipper Transcription Factors
dc.subjectCircadian Clocks
dc.subjectGlucosyltransferases
dc.subjectProtein Serine-Threonine Kinases
dc.subjectRepressor Proteins
dc.subjectSucrose
dc.subjectSugar Phosphates
dc.subjectSugars
dc.subjectTrehalose
dc.titleCircadian Entrainment in Arabidopsis by the Sugar-Responsive Transcription Factor bZIP63.
dc.typeArticle
dcterms.dateAccepted2018-05-31
prism.endingPage2606.e6
prism.issueIdentifier16
prism.publicationDate2018
prism.publicationNameCurr Biol
prism.startingPage2597
prism.volume28
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/H006826/1)
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M006212/1)
pubs.funder-project-idBritish Council (150801430)
rioxxterms.licenseref.startdate2018-08-02
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.cub.2018.05.092

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
1-s2.0-S0960982218307620-main.pdf
Size:
2.22 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
https://creativecommons.org/licenses/by/4.0/
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
DepositLicenceAgreement.pdf
Size:
417.78 KB
Format:
Adobe Portable Document Format
Download

Collections

Cambridge University Research Outputs