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Oxygen regulation of TET enzymes.

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cam.issuedOnline2021-01-29
dc.contributor.authorMatuleviciute, Rugile
dc.contributor.authorCunha, Pedro P
dc.contributor.authorJohnson, Randall S
dc.contributor.authorFoskolou, Iosifina P
dc.contributor.orcidJohnson, Randall S [0000-0002-4084-6639]
dc.date.accessioned2022-01-05T16:29:26Z
dc.date.available2022-01-05T16:29:26Z
dc.date.issued2021-12
dc.date.submitted2020-10-29
dc.date.updated2022-01-05T16:29:25Z
dc.description.abstractHypoxia has a significant impact on many physiological and pathological processes. Over the recent years, its role in modulation of epigenetic remodelling has also become clearer. In cancer, low oxygen environments and aberrant epigenomes often go hand in hand, and changes in DNA methylation are now commonly recognised as potential outcome indicators. TET (ten-eleven translocation) family enzymes are alpha-ketoglutarate-, iron- and oxygen-dependent DNA demethylases and are key players in these processes. Although TETs have historically been considered tumour suppressors, recent studies suggest that their functions in cancer might not be straightforward. Recently, inhibition of TETs has been reported to have positive impact in cancer immunotherapy and vaccination studies. This underlines the current interest in developing targeted pharmaceutical inhibitors of these enzymes. Here, we will survey the complexity of TET roles in cancer, and its hypoxic modulation, as well as highlight the potential of these enzymes as therapeutic targets.
dc.identifier.doi10.17863/CAM.79496
dc.identifier.eissn1742-4658
dc.identifier.issn1742-464X
dc.identifier.otherfebs15695
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/332049
dc.languageen
dc.language.isoeng
dc.publisherWiley
dc.publisher.urlhttp://dx.doi.org/10.1111/febs.15695
dc.subject5hmC
dc.subjectTET
dc.subjectcancer
dc.subjecthypoxia
dc.subjectimmunotherapy
dc.subjectα-KG-dependent enzymes
dc.subjectAnimals
dc.subjectHumans
dc.subjectMixed Function Oxygenases
dc.subjectNeoplasms
dc.subjectOxygen
dc.titleOxygen regulation of TET enzymes.
dc.typeArticle
dcterms.dateAccepted2021-01-04
prism.endingPage7161
prism.issueIdentifier24
prism.publicationNameFEBS J
prism.startingPage7143
prism.volume288
pubs.funder-project-idWellcome Trust (214283/Z/18/Z)
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1111/febs.15695

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