Repository logo
 

Interplay between mechanics and signalling in regulating cell fate.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

De Belly, Henry 

Abstract

Mechanical signalling affects multiple biological processes during development and in adult organisms, including cell fate transitions, cell migration, morphogenesis and immune responses. Here, we review recent insights into the mechanisms and functions of two main routes of mechanical signalling: outside-in mechanical signalling, such as mechanosensing of substrate properties or shear stresses; and mechanical signalling regulated by the physical properties of the cell surface itself. We discuss examples of how these two classes of mechanical signalling regulate stem cell function, as well as developmental processes in vivo. We also discuss how cell surface mechanics affects intracellular signalling and, in turn, how intracellular signalling controls cell surface mechanics, generating feedback into the regulation of mechanosensing. The cooperation between mechanosensing, intracellular signalling and cell surface mechanics has a profound impact on biological processes. We discuss here our understanding of how these three elements interact to regulate stem cell fate and development.

Description

Keywords

Biological Phenomena, Cell Differentiation, Mechanotransduction, Cellular, Morphogenesis, Signal Transduction

Journal Title

Nat Rev Mol Cell Biol

Conference Name

Journal ISSN

1471-0072
1471-0080

Volume Title

Publisher

Springer Science and Business Media LLC
Sponsorship
European Research Council (772798)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (641639)
European Research Council (820188)