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Looking back on the alternative complement pathway.

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cam.issuedOnline2018-03-06
dc.contributor.authorLachmann, Peter J
dc.contributor.orcidLachmann, Sir Peter [0000-0003-2849-3524]
dc.date.accessioned2019-04-30T13:58:42Z
dc.date.available2019-04-30T13:58:42Z
dc.date.issued2018-08
dc.description.abstractThe alternative pathway of complement originated from the Properdin pathway originally described by the Pillemer laboratory in the 1950s. This work generated great controversy and it took several decades for a consensus on its components, its reaction sequence and its functions to emerge. This paper reviews this history and attempts to clarify some of the ambiguities that remain.
dc.identifier.doi10.17863/CAM.39281
dc.identifier.eissn1878-3279
dc.identifier.issn0171-2985
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/292129
dc.languageeng
dc.language.isoeng
dc.publisherElsevier
dc.publisher.urlhttps://www.sciencedirect.com/science/article/pii/S0171298518300184?via%3Dihub#ack0005
dc.subjectAlternative pathway
dc.subjectComplement
dc.subjectProperdin
dc.subjectAnimals
dc.subjectComplement Pathway, Alternative
dc.subjectHistory, 20th Century
dc.subjectHistory, 21st Century
dc.subjectHumans
dc.subjectProperdin
dc.titleLooking back on the alternative complement pathway.
dc.typeArticle
dcterms.dateAccepted2018-02-27
prism.endingPage523
prism.issueIdentifier8-9
prism.publicationDate2018
prism.publicationNameImmunobiology
prism.startingPage519
prism.volume223
rioxxterms.licenseref.startdate2018-08
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1016/j.imbio.2018.02.001

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