The rapid generation of isothiocyanates in flow.
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Peer-reviewed
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Abstract
Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.
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Keywords
chloroxime, dipolar cycloaddition, flow chemistry, flow synthesis, immobilised reagents, isothiocyanate, nitrile oxide
Journal Title
Beilstein J Org Chem
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Journal ISSN
1860-5397
1860-5397
1860-5397
Volume Title
9
Publisher
Beilstein Institut