The rapid generation of isothiocyanates in flow.


Type
Article
Change log
Authors
Abstract

Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.

Description
Keywords
chloroxime, dipolar cycloaddition, flow chemistry, flow synthesis, immobilised reagents, isothiocyanate, nitrile oxide
Journal Title
Beilstein J Org Chem
Conference Name
Journal ISSN
1860-5397
1860-5397
Volume Title
9
Publisher
Beilstein Institut