The Role of lncRNAs and miRNAs in Therapy-Induced Senescence in Neuroblastoma

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Ishola, Tala 

jats:titleAbstract</jats:title>jats:sec jats:titlePurpose of Review</jats:title> jats:pNeuroblastoma, a paediatric malignancy of the sympathoadrenal lineage with a variable clinical course, is the most prevalent extra-cranial cancer in children. The majority of multi-modal therapeutics utilised for treating neuroblastoma may drive cells towards cell death or cellular senescence.</jats:p> </jats:sec>jats:sec jats:titleRecent Findings</jats:title> jats:pAlthough cellular senescence has been historically regarded as a permanent state of non-proliferation, new evidence supports the notion that this process may indeed be much more dynamic than previously thought. Further, senescent tumour cells may escape treatment and further promote inflammation and migration through their repertoire of secreted molecules, leading to disease relapse.</jats:p> </jats:sec>jats:sec jats:titleSummary</jats:title> jats:pGiven this background, we review here the role of non-coding RNAs inclusive of long non-coding RNAs (lncRNAs) and miRNAs in therapy-induced senescence-related processes in neuroblastoma and discuss how these molecules may be manipulated for therapeutic gain.</jats:p> </jats:sec>

3101 Biochemistry and Cell Biology, 31 Biological Sciences, Neuroblastoma, Orphan Drug, Pediatric, Rare Diseases, Cancer, Genetics, Neurosciences, 2.1 Biological and endogenous factors, 2 Aetiology, Cancer
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Current Molecular Biology Reports
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Springer Science and Business Media LLC