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Imaging and treatment of brain tumors through molecular targeting: Recent clinical advances.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Zaccagna, Fulvio 
Grist, James T 
Quartuccio, Natale 
Riemer, Frank 
Fraioli, Francesco 

Abstract

Molecular imaging techniques have rapidly progressed over recent decades providing unprecedented in vivo characterization of metabolic pathways and molecular biomarkers. Many of these new techniques have been successfully applied in the field of neuro-oncological imaging to probe tumor biology. Targeting specific signaling or metabolic pathways could help to address several unmet clinical needs that hamper the management of patients with brain tumors. This review aims to provide an overview of the recent advances in brain tumor imaging using molecular targeting with positron emission tomography and magnetic resonance imaging, as well as the role in patient management and possible therapeutic implications.

Description

Keywords

Brain tumor, Glioma, MRI, Molecular imaging, PET, Theranostics, Brain Neoplasms, Humans, Magnetic Resonance Imaging, Molecular Targeted Therapy, Positron-Emission Tomography, Tomography, X-Ray Computed

Journal Title

Eur J Radiol

Conference Name

Journal ISSN

0720-048X
1872-7727

Volume Title

142

Publisher

Elsevier BV
Sponsorship
Royal Society (IE150411)
Cancer Research UK (C12912/A27150)
Lundbeck Foundation (via Aarhus University) (L. Hanberg/J.Gaarde Kristensen)
National Institute for Health and Care Research (IS-BRC-1215-20014)
Cancer Research Uk (None)