Here, we present a comprehensive study of self-driven flow dynamics at the liquid-gas interface within nanofluidic pores in the absence of external driving forces. The investigation focuses on the Rayleigh-Taylor instability phenomena that occur in sub-100 nm scale fluidic pores interfacing between 2 μm scale water and air reservoir. We obtain a flow velocity equation, and we validate it using simulations, concentrating on the mass transfer efficiency of these flow structures. Furthermore, we introduce the concept─"active solid-state nanopore"─that exhibits a self-driven flow switching behavior, transitioning between active and passive states without the need for mechanical components. We found a unique state of chaos at the nanoscale resembling the chaotic motion of fluid. This study contributes to the preliminary understanding of fluid dynamics at the classical-quantum interface. Implications of self-driven nanofluidics extend across diverse fields from biosensing and healthcare applications to advancing net-zero sustainable energy production and contributing to the fundamental understanding of fluid dynamics in confined spaces.