Evolutionary dynamics in pre-invasive neoplasia.
| cam.issuedOnline | 2017-03-09 | |
| dc.contributor.author | Abbosh, Christopher | |
| dc.contributor.author | Venkatesan, Subramanian | |
| dc.contributor.author | Janes, Samuel M | |
| dc.contributor.author | Fitzgerald, Rebecca C | |
| dc.contributor.author | Swanton, Charles | |
| dc.contributor.orcid | Fitzgerald, Rebecca [0000-0002-3434-3568] | |
| dc.date.accessioned | 2018-09-21T15:22:39Z | |
| dc.date.available | 2018-09-21T15:22:39Z | |
| dc.date.issued | 2017-04 | |
| dc.description.abstract | Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations. | |
| dc.format.medium | ||
| dc.identifier.doi | 10.17863/CAM.28021 | |
| dc.identifier.eissn | 2452-3100 | |
| dc.identifier.issn | 2452-3100 | |
| dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/280655 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier BV | |
| dc.publisher.url | http://dx.doi.org/10.1016/j.coisb.2017.02.009 | |
| dc.subject | Intratumor heterogeneity | |
| dc.subject | cancer evolution | |
| dc.subject | field cancerization | |
| dc.subject | genomic instability | |
| dc.subject | pre-invasive neoplasia | |
| dc.title | Evolutionary dynamics in pre-invasive neoplasia. | |
| dc.type | Article | |
| dcterms.dateAccepted | 2017-03-09 | |
| prism.endingPage | 8 | |
| prism.publicationDate | 2017 | |
| prism.publicationName | Curr Opin Syst Biol | |
| prism.startingPage | 1 | |
| prism.volume | 2 | |
| rioxxterms.licenseref.startdate | 2017-04 | |
| rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
| rioxxterms.type | Journal Article/Review | |
| rioxxterms.version | AM | |
| rioxxterms.versionofrecord | 10.1016/j.coisb.2017.02.009 |
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