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Evolutionary dynamics in pre-invasive neoplasia.

Accepted version
Peer-reviewed

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Authors

Abbosh, Christopher 
Venkatesan, Subramanian 
Janes, Samuel M 
Fitzgerald, Rebecca C 
Swanton, Charles 

Abstract

Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations.

Description

Keywords

Intratumor heterogeneity, cancer evolution, field cancerization, genomic instability, pre-invasive neoplasia

Journal Title

Curr Opin Syst Biol

Conference Name

Journal ISSN

2452-3100
2452-3100

Volume Title

2

Publisher

Elsevier BV