Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.


Type
Article
Change log
Authors
Cook, Alexander D 
Webb, Helena 
Crow, Mandy 
Burns, Roisin 
Abstract

African trypanosomes are extracellular pathogens of mammals and are exposed to the adaptive and innate immune systems. Trypanosomes evade the adaptive immune response through antigenic variation, but little is known about how they interact with components of the innate immune response, including complement. Here we demonstrate that an invariant surface glycoprotein, ISG65, is a receptor for complement component 3 (C3). We show how ISG65 binds to the thioester domain of C3b. We also show that C3 contributes to control of trypanosomes during early infection in a mouse model and provide evidence that ISG65 is involved in reducing trypanosome susceptibility to C3-mediated clearance. Deposition of C3b on pathogen surfaces, such as trypanosomes, is a central point in activation of the complement system. In ISG65, trypanosomes have evolved a C3 receptor which diminishes the downstream effects of C3 deposition on the control of infection.

Description
Keywords
Animals, Complement C3, Macrophage-1 Antigen, Mammals, Membrane Glycoproteins, Mice, Protozoan Proteins, Trypanosoma, Trypanosoma brucei brucei
Journal Title
Nat Commun
Conference Name
Journal ISSN
2041-1723
2041-1723
Volume Title
13
Publisher
Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (217138/Z/19/Z)